IGF-1 and HGH Composition for Cochlear Hair Cell Recovery
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Solution Overview
Problem
Sensorineural hearing loss in mammals, caused by cellular degradation and oxidative stress, leads to progressive loss of hearing and other age-related issues, with existing treatments only marginally improving hearing volume without addressing word recognition.
Innovation Solution
A pharmaceutically acceptable composition containing IGF-1 and human growth hormone in a 5:2 ratio by weight, topically administered every three days, directly penetrates the inner ear to regulate sodium and potassium levels in cochlear hair cells, improving hearing parameters such as volume and word recognition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If conventional hearing aids are used to improve hearing volume, then hearing volume may be marginally improved, but word recognition remains unaffected and device complexity increases
Solution Approach 1:
The patent replaces mechanical hearing aid devices with a biochemical solution - topical application of IGF-1 and human growth hormone compositions that directly treat the underlying cellular degradation in cochlear hair cells, eliminating the need for complex mechanical amplification devices while improving both hearing volume and word recognition
Solution Approach 2:
The patent uses IGF-1 and human growth hormone as intermediary substances that mediate between the applied composition and the cochlear hair cells, regulating sodium and potassium levels to restore cellular function and improve hearing parameters without requiring complex external devices
2Reliability
If continuous topical application is used to maintain therapeutic effect, then hearing improvement is sustained, but loss of time due to frequent application increases
Solution Approach 1:
The patent implements periodic action by recommending intermittent application of the composition every three days rather than continuous daily application, allowing receptor sites to recharge between applications while maintaining sustained therapeutic effect on cochlear hair cells
Solution Approach 2:
The patent applies preliminary action by using a composition formulated with IGF-1 and human growth hormone in specific ratios that prepares and protects cochlear hair cells in advance, creating a sustained therapeutic effect that lasts through the intermittent application interval
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves significant improvements in hearing volume up to 40 dB and word recognition by 38.85%, surpassing conventional hearing aids and other treatments, with optimal results from intermittent application allowing receptor site recharge.
Implementation Method 1
hormones provide greater regulation of sodium and potassium levels in the delicate sound-detecting hair cells
Data Source
AI summary
The present invention is directed to compositions and methods for improving hearing parameters in a human (including hearing volume, hearing range and word recognition) by reversing or inhibiting damage to cochlear cells caused by toxic byproducts of oxygen metabolism. In a preferred embodiment, a pharmaceutically acceptable composition containing insulin-like growth factor one (IGF-1) and human growth hormone (HGH), or their derivatives in a 5:2 ratio by weight, is topically administered every three days in a dosage of 0.1 to 2 mcg per kilogram of body weight. The composition directly penetrates the inner ear and cochlea to provide greater regulation of sodium and potassium levels in the delicate sound-detecting hair cells. In accordance with the present invention, mean word recognition was improved by nearly 39 percent, hearing volume was improved by up to 40 dB, and the hearing range was improved above 6,000 Hz.