Ignition-Driven Injector for Direct Cell Nucleus Biomolecule Delivery
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Solution Overview
Problem
Existing injectors lack the capability to directly inject solutions containing biomolecules into the cell nucleus of a wide range of injection targets with high efficiency.
Innovation Solution
An injector that utilizes an ignition device with an ignition charge to pressurize a solution containing biomolecules, achieving an injection speed of 75 m/s to 150 m/s for 0.11 ms or longer, allowing direct injection into cell nuclei.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional injection methods (catheters, needle syringes, needleless syringes) are used, then injection can be performed through existing structures, but direct injection into cell nucleus with high efficiency cannot be achieved
Solution Approach 1:
The invention extracts and eliminates the intermediate catheter or needle structure from the injection path. The injector directly propels the biomolecule solution into the cell nucleus without requiring a catheter to be inserted into the target, thereby achieving direct nuclear injection with high efficiency while simplifying the overall injection structure.
Solution Approach 2:
The invention replaces conventional mechanical injection systems (pistons, springs, pressurized gases) with an ignition-based propulsion system. The ignition charge creates a rapid pressure wave that propels the solution at controlled speeds (75-150 m/s) directly into the cell nucleus, achieving precise nuclear delivery without complex mechanical injection mechanisms.
2Speed
If high injection speed is achieved using ignition charge, then direct nuclear injection efficiency improves, but injection speed control precision must be maintained within specific range
Solution Approach 1:
The invention precisely controls the injection speed by adjusting parameters of the ignition system, including the amount of ignition charge, chamber geometry, and solution properties. The ignition charge is calibrated to generate pressure waves that propel the solution at speeds within the specific range of 75-150 m/s, ensuring optimal nuclear injection efficiency while maintaining precise speed control.
Solution Approach 2:
The ignition-based system creates a controlled, transient pressure wave that propels the solution in a brief, intense pulse. This periodic action (ignition event) delivers the solution to the nucleus with precise speed control, maintaining the required velocity range for the brief duration needed for nuclear penetration while avoiding excessive speeds that could damage the nucleus.
3Speed
If injection speed is increased to penetrate cell structures, then injection efficiency improves, but duration of injection must be maintained for adequate delivery
Solution Approach 1:
The ignition system generates a brief, intense pressure wave that propels the solution at high speed (75-150 m/s) for a very short duration. This pulsed action is sufficient to penetrate cell structures and deliver biomolecules directly into the nucleus, maintaining both the required speed for efficient penetration and the adequate duration for complete nuclear delivery.
Solution Approach 2:
The ignition-based propulsion system ensures continuous delivery of the solution throughout the brief injection event. The pressure wave maintains consistent propulsion force from the moment of ignition until the solution is fully delivered into the nucleus, ensuring uninterrupted and efficient nuclear injection without interruption or loss of momentum.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The injector enables high-efficiency direct injection of biomolecules into cell nuclei across a wide range of targets, facilitating efficient gene expression.
Implementation Method 1
the solution being pressurized by combustion of an ignition charge in an ignition device
Data Source
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AI summary
An object of the present invention is to provide an injector that can directly inject a solution containing biomolecules into a cell nucleus of a wide range of injection targets with high efficiency; and the object is fulfilled by an injector that injects a solution containing biomolecules into an injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target, the injector comprising: an accommodation unit for accommodating a solution containing biomolecules; and a nozzle unit including an injection port through which the solution containing biomolecules flows and is injected into the injection target, the solution being pressurized by combustion of an ignition charge in an ignition device, wherein a maximum injection speed of the solution containing biomolecules between an injection start time of the solution containing biomolecules and a time of 0.20 ms is from 75 m/s to 150 m/s and an injection speed of the solution containing biomolecules of from 75 m/s to 150 m/s lasts for 0.11 ms or longer.