Imaging Capsule Compton Backscattering Inflamed Area Detection

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Solution Overview

Problem

Current radiation-based imaging capsules for diagnosing and treating gastrointestinal diseases lack accuracy in identifying inflamed areas within the gastrointestinal tract, which hinders precise treatment delivery.

Innovation Solution

An imaging capsule equipped with a radiation source, collimator, and detectors that use Compton backscattering counts and radiation from radioactively labeled tissue to identify inflamed areas, allowing for targeted scanning and medication release.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional imaging capsules are used for gastrointestinal scanning, then basic imaging can be achieved, but accuracy in identifying inflamed areas is insufficient

Engineering Contradiction:
Improveaccuracy in identifying inflamed areasVSAvoidcomplexity of imaging capsule system
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The imaging capsule system is segmented into multiple functional modules: radiation source module, collimator module, detector module (including Compton backscattering detector and X-ray fluorescence detector), and processing unit. Each module performs a specific function, allowing the system to achieve high measurement precision for identifying inflamed areas while managing device complexity through modular design.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The imaging capsule is designed with multi-functionality to address various diagnostic needs. It can detect Compton backscattering radiation, X-ray fluorescence radiation, and potentially other radiation types, enabling it to identify different types of gastrointestinal conditions including inflamed areas, tumors, and structural abnormalities with a single device.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If radiation-based imaging is used to scan the gastrointestinal tract, then images can be reconstructed, but precise localization of inflamed areas relative to non-inflamed areas is difficult

Engineering Contradiction:
Improvelocalization accuracy of inflamed areasVSAvoiddifficulty in distinguishing inflamed from non-inflamed areas
Core Design Contradiction:
Measurement precisionVSDifficulty of detecting and measuring

Solution Approach 1:

The patent introduces radioactively labeled compounds as intermediaries that selectively accumulate in inflamed areas. These labeled compounds emit characteristic radiation that serves as a mediator between the inflamed tissue and the detectors, enabling precise localization and clear distinction between inflamed and non-inflamed areas through spectral analysis.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system utilizes changes in radiation parameters (energy, intensity, scattering angle) to differentiate inflamed from non-inflamed areas. By analyzing the energy spectrum of detected radiation and the angular distribution of Compton backscattering, the system can precisely localize inflamed areas based on distinct radiation signatures.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the accuracy of identifying inflamed areas and enables precise treatment delivery by reconstructing images and releasing medication directly to affected regions, improving diagnostic and therapeutic outcomes.

Implementation Method 1

the imaging capsule is configured to identify an inflamed area based on measurements of the detectors in the imaging capsule. For example based on Compton backscattering counts, which are proportional to the density of the surrounding tissue.

Methodology Applied
Scientific EffectCompton backscattering: Compton Scattering

Implementation Method 2

At least one detector configured to detect particles resulting from X-ray fluorescence and/or Compton backscattering

Methodology Applied
Scientific EffectX-ray fluorescence: Fluorescence

Implementation Method 3

the imaging capsule is configured to detect the inflamed area based on detection of radiation from radioactively labeled tissue of the inflamed area

Methodology Applied
Scientific EffectRadioactive decay: Radioactive Decay

Data Source

PatentUS12251251B2Radiation capsule for bowel disease imaging and localize drug delivery
Publication Date: 2025.03.18 CHECK CAP LTD
  • US12251251B2 patent drawing
  • US12251251B2 patent drawing
  • US12251251B2 patent drawing

AI summary

An imaging capsule including, a radiation source, a collimator that provides a collimated beam from the radiation source, at least one detector configured to detect particles resulting from X-ray fluorescence and/or Compton backscattering in response to the collimated beam to reconstruct images of a user's gastrointestinal tract, wherein the imaging capsule is configured to identify an inflamed area, within the user's gastrointestinal tract, based on a count of the detected particles and initiate actions responsive to detecting the inflamed area.