Imaging Cytometer and Blood Cell Analyzer Integration
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Solution Overview
Problem
Conventional cytometry techniques, such as flow cytometry and imaging cytometry, face challenges in performing accurate analysis of cells, as they either lack detailed morphological information or struggle with obtaining sufficient statistics.
Innovation Solution
An analyzing system combining an imaging cytometer and a blood cell analyzing apparatus, utilizing both electrical resistance and optical analyzing methods, to acquire detailed information by imaging particles and performing quantitative analysis, thereby overcoming the limitations of conventional systems.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If flow cytometry is used to analyze cells, then a large amount of cells can be quantitatively analyzed, but detailed information of cell morphology cannot be obtained
Solution Approach 1:
The patent combines flow cytometry and imaging cytometry into a single integrated system. The flow cytometry component handles high-speed quantitative analysis of large cell populations, while the imaging cytometry component captures morphological images of cells. By merging these two previously separate techniques, the system simultaneously achieves both high productivity and detailed morphological information without requiring separate analysis procedures.
2Loss of information
If imaging cytometry is used to obtain detailed information of cell morphology, then detailed information of the cell morphology can be obtained, but it is difficult to obtain a sufficient amount of statistics
Solution Approach 1:
The integrated system merges imaging cytometry with flow cytometry, where the flow cytometry component provides high-speed processing capability to analyze large numbers of cells. This combination allows the system to capture detailed morphological images while simultaneously maintaining the statistical power needed for sufficient data analysis, overcoming the limitation of traditional imaging cytometry which processes cells too slowly for adequate statistical sampling.
3Loss of information
If only imaging cytometry is used for cell analysis, then detailed morphological information can be acquired, but analysis time and costs increase
Solution Approach 1:
The system applies partial imaging action by using imaging cytometry only for specific cell types or abnormal cells identified by the flow cytometry component. Rather than imaging all cells in the sample, the system first performs rapid flow cytometry analysis to identify cells of interest, then applies imaging only to those specific cells. This selective approach reduces overall analysis time and resource consumption while still acquiring necessary morphological information.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combined system enables the acquisition of detailed information and flexible testing, allowing for accurate analysis of cells that cannot be achieved by conventional methods, improving analysis speed and reducing medical costs by only using the imaging cytometer when necessary.
Implementation Method 1
suspended cells are guided into a sensing zone, and scattered light, fluorescent light, and the like are measured at high speed
Implementation Method 2
suspended cells are guided into a sensing zone, and scattered light, fluorescent light, and the like are measured at high speed
Implementation Method 3
a blood cell analyzing apparatus configured to analyze particles contained in an analyte sample by at least one of an electrical resistance method and an optical analyzing method
Data Source
AI summary
An analyzing system includes an imaging cytometer having a first imaging section configured to perform an imaging of particles contained in an analyte sample to generate images, the imaging cytometer being configured to analyze the images generated by the first imaging section, and a blood cell analyzing apparatus configured to analyze particles contained in the analyte sample by at least one of an electrical resistance method and an optical analyzing method. One of the imaging cytometer and the blood cell analyzing apparatus has an analyzing section configured to produce a report of an analysis of the analyte sample based on particle information acquired by the imaging cytometer and particle information acquired by the blood cell analyzing apparatus.