Imaging Mass Spectrometer Data Matrix Creation During Acquisition
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Solution Overview
Problem
The increasing amount of data generated by advanced imaging mass spectrometers, due to improved mass-resolving power and spatial resolution, leads to lengthy data matrix creation times, causing user stress and inefficiency in the workflow from data collection to multivariate analysis.
Innovation Solution
An imaging mass spectrometer with an analysis execution section, a condition memory section to store data matrix creation conditions, and a data matrix creation section that begins creating the data matrix concurrently with or after data collection, allowing for immediate initiation of multivariate analysis without user intervention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If data collection is performed with high mass-resolving power and spatial resolution, then measurement precision and image quality are improved, but the total amount of data increases dramatically, leading to extended data matrix creation time
Solution Approach 1:
The system performs preliminary actions by storing data matrix creation conditions before analysis execution and automatically creating the data matrix during or after data collection. This preliminary preparation eliminates the need for manual intervention later, reducing the time users need to wait for multivariate analysis.
Solution Approach 2:
The imaging mass spectrometer performs self-service by automatically creating the data matrix without requiring user intervention. The system uses stored conditions to autonomously process the enormous data volume generated by high-resolution measurements, converting raw data into analysis-ready format automatically.
2Measurement precision
If the number of data points in the mass-to-charge-ratio direction is increased to improve mass-resolving power, then measurement precision is improved, but the total amount of data increases, causing productivity to decrease
Solution Approach 1:
The system performs self-service by automatically creating the data matrix without requiring user intervention. The system uses stored conditions to autonomously process the enormous data volume generated by high-resolution measurements, converting raw data into analysis-ready format automatically.
Solution Approach 2:
The data matrix creation process runs continuously during or after data collection without interruption. This continuous processing ensures that the system maintains high productivity by eliminating idle time between data acquisition and analysis preparation.
3Measurement precision
If manual data matrix creation is performed after data collection, then data processing accuracy is maintained, but user wait time increases significantly, reducing ease of operation
Solution Approach 1:
The system performs preliminary actions by storing data matrix creation conditions before analysis execution and automatically creating the data matrix during or after data collection. This preliminary preparation eliminates the need for manual intervention later, reducing the time users need to wait for multivariate analysis.
Solution Approach 2:
The imaging mass spectrometer performs self-service by automatically creating the data matrix without requiring user intervention. The system uses stored conditions to autonomously process the enormous data volume generated by high-resolution measurements, converting raw data into analysis-ready format automatically.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces user wait time and improves efficiency by completing the data matrix during data acquisition, enabling prompt initiation of multivariate analysis and reducing the overall analysis period, while allowing for immediate display of mass spectrometric imaging graphics.
Implementation Method 1
One measurement point included in a two-dimensional range set on a sample is irradiated with an ionization probe, such as a thin laser beam, to ionize sample components which exist at the measurement point
Implementation Method 2
the thereby generated ions, or secondary ions produced from those ions by a dissociation or similar process, are subjected to mass spectrometry
Data Source
AI summary
An imaging mass spectrometer according to one mode of the present invention includes: an analysis execution section (1, 31) configured to perform a mass spectrometric analysis on each of a plurality of measurement points set within a two-dimensional area on a sample, to collect mass spectrum data over a predetermined mass-to-charge-ratio range for each measurement point; a condition memory section (32) configured to store a data matrix creation condition to be used for creation of a data matrix based on the mass spectrum data acquired by the analysis in the analysis execution section; and a data matrix creation section (42) configured to begin, in the middle of an execution of the analysis by the analysis execution section or subsequently to the completion of the analysis, the creation of the data matrix based on mass spectrum data already collected until then, according to the data matrix creation condition stored in the condition memory section.