Imazalil and Silver Compound Synergistic Biocidal Compositions

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Solution Overview

Problem

Current biocidal compositions for protecting materials against microorganisms lack a synergistic effect between inorganic and organic components, which limits their efficacy in controlling a broad range of microorganisms such as bacteria, fungi, and viruses.

Innovation Solution

A combination of imazalil, or its salt, with specific silver compounds like silver acetate, silver alginate, and silver nitrate, which provides a synergistic biocidal effect when applied in specific proportions, enhancing the control of microorganisms on various materials and surfaces.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional biocidal compositions use inorganic and organic components separately, then the composition is simple to formulate, but the biocidal efficacy is limited and no synergistic effect is achieved

Engineering Contradiction:
Improvebiocidal efficacyVSAvoidcomposition complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines inorganic silver compounds and organic imazalil in a single biocidal composition, allowing the two components to work synergistically together rather than separately, thereby enhancing overall biocidal efficacy while maintaining formulation simplicity

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite biocidal system by integrating inorganic silver compounds with organic imazalil, leveraging the complementary properties of both material types to achieve superior antimicrobial, antifungal, and antiviral effects compared to single-component systems

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If biocidal compositions use only single components or non-synergistic combinations, then the formulation is straightforward, but the control of broad-spectrum microorganisms is insufficient

Engineering Contradiction:
Improvebroad-spectrum coverageVSAvoidformulation complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The combined composition of silver compounds and imazalil provides multi-functional biocidal activity, effectively controlling bacteria, fungi, and viruses simultaneously, making it a universal solution for broad-spectrum microorganism control without requiring separate formulations for different pathogen types

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentEP1993361B1Combinations of imazalil and silver compounds
Publication Date: 2015.07.22 JANSSEN PHARMA NV
  • EP1993361B1 patent drawing
  • EP1993361B1 patent drawing

AI summary

The present invention relates to combinations of imazalil, or a salt thereof, and silver compounds which provide an improved biocidal effect. More particularly, the present invention relates to compositions comprising a combination of imazalil, or a salt thereof, together with one or more silver salts selected from silver acetate, silver alginate, silver azide, silver citrate, silver lactate, silver nitrate; silver perchlorate/ silver sulfate, silver chloride, silver thiocyanate, silver-sodium-hydrogen-zirconium phosphate, silver sulfadiazine, silver cyclohexanediacetic acid and disilver 2,5-dichloro-3,6-dihydroxy-2,5-cyclohexadiene-1,4-dione; in respective proportions to provide a synergistic biocidal effect. Other suitable silver components (II) are products that set silver free using technologies to make it gradually biologically available such as by ion exchange mechanisms such like using zirconium phosphate based ceramics as a reservoir, or silver provided in glass ceramics as reservoir or carrier, or silver provided with zeolites, silica gel or titanium dioxide as a reservoir or an inorganic derivative containing silver, incorporated into a plastic composition for the preparation of moulded, lacquered or painted products, such as an amino resin (e.g. urea-formaldehyde resin, melamine formaldehyde resin...) or a thermoplastic (e.g. a polyester, polyethylene, polyacrylate, pvc...), or provided as nano-silver particles typically with a particle size of 20-1000 nm. Compositions comprising these combinations are useful for the protection of any living or non-living material, such as crops, plants, fruits, seeds, objects made of wood, thatch or the like, biodegradable material and textiles against deterioration due to the action of microorganisms such as bacteria, fungi, yeasts, algae, and the like.