Imidazole Dipeptide Formulation for Cramp Relief

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Solution Overview

Problem

Current treatments for muscle cramps and spasms, such as quinine and botulinum toxin, are either ineffective in reducing frequency or come with adverse effects, highlighting a need for a more effective and safer solution.

Innovation Solution

A formulation comprising a dipeptide composition with >10% imidazole-containing dipeptides, a turmeric product with >15% curcumin, and ancient peat minerals, which can be administered to treat cramps and spasms, reduce their frequency, and improve associated symptoms.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If quinine is used to treat cramps and spasms, then cramp frequency is reduced, but adverse effects such as cinchonism, hypoglycemia, hypotension, hearing and visual disturbances, and hemolysis occur

Engineering Contradiction:

Improvecramp frequency reductionVSAvoidadverse effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by using a dipeptide composition containing imidazole-containing dipeptides (e.g., carnosine, anserine) instead of quinine, thereby achieving cramp frequency reduction without the harmful side effects associated with quinine therapy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a composite formulation combining dipeptide composition, turmeric product containing curcumin, and ancient peat minerals to create a synergistic treatment that addresses cramps and spasms while avoiding the adverse effects of single-agent therapies like quinine

Inventive Principle:

Principle #40Composite materials

2Reliability

If botulinum toxin is injected to treat cramps, then local cramp treatment is achieved, but invasive treatment reduces patient compliance and causes adverse effects such as redness, swelling, pain, and local muscle weakness

Engineering Contradiction:

Improvelocal cramp treatmentVSAvoidpatient compliance

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces the mechanical injection system of botulinum toxin with an oral formulation containing dipeptide composition, turmeric product, and ancient peat minerals, thereby eliminating the invasive procedure and improving patient compliance while maintaining therapeutic effectiveness

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent uses dietary supplements (dipeptide composition, curcumin, peat minerals) as intermediary substances that can be administered orally to achieve cramp treatment without requiring direct injection into the muscle, thus avoiding the adverse effects and compliance issues associated with botulinum toxin injections

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS12201667B2Formulations for treating cramps and spasms

Publication Date: 2025.01.21 LYTONE ENTERPRISE INC

AI summary

The present invention provides a formulation capable of treating cramp and/or spasm in a subject, or reducing frequency of cramp and/or spasm in a subject, wherein the formulation comprises a dipeptide composition containing one or more imidazole-containing dipeptides, a turmeric product containing curcumin, and ancient peat minerals.