Imidazole Compounds for Targeted ER Stress Modulation

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Solution Overview

Problem

Existing therapies for autoimmune disorders, particularly those targeting endoplasmic reticulum (ER) stress, provide only symptomatic relief and have significant side effects, lacking targeted and effective treatments for conditions like vitiligo and other autoimmune diseases.

Innovation Solution

Development of novel imidazole compounds that modulate ER stress pathways, reducing stress-mediated cell death and aberrant immune regulation, offering potential therapeutic benefits for autoimmune diseases, cancers, and dermatological disorders.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing therapies for autoimmune disorders are used, then symptomatic relief is achieved, but side effects occur and targeted treatment is insufficient

Engineering Contradiction:

Improvetherapeutic effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent modifies molecular parameters by synthesizing novel imidazole compounds with specific substituent patterns (R1-R8 groups) to optimize binding affinity and selectivity for ER stress pathways, achieving targeted treatment with reduced side effects compared to conventional therapies

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The imidazole compounds act as intermediary agents that specifically modulate ER stress pathways, serving as a bridge between the therapeutic goal and the disease mechanism, thereby providing targeted relief without the broad side effects of conventional immunosuppressants

Inventive Principle:

Principle #24Intermediary (Mediator)

2Adaptability or versatility

If conventional autoimmune therapies are administered, then treatment is provided, but targeted therapy is lacking

Engineering Contradiction:

Improvetargeted treatment capabilityVSAvoidtherapeutic effectiveness

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent applies local quality by designing imidazole compounds with specific structural features (substituents at positions 1, 2, 4, and 5 of the imidazole ring) that confer selective activity against ER stress pathways in specific cell types, enabling targeted therapy for particular autoimmune conditions

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The therapeutic approach is segmented into specific molecular targets (ER stress pathways) and specific compound classes (imidazole compounds with defined substituents), allowing for precise modulation of disease mechanisms rather than broad immunosuppression

Inventive Principle:

Principle #1Segmentation

Data Source

PatentUS20260001850A1Novel imidazole compounds, process for the synthesis and uses thereof

Publication Date: 2026.01.01 AHAMMUNE BIOSCIENCES PRIVATE LIMITED

AI summary

The present invention relates to novel pharmaceutical agents and the process of preparation thereof. The present invention discloses compounds of general formula I, and the process of their preparation. The compounds of the invention are useful in the treatment and prevention of diseases related to cellular stress mediated immune deregulation and loss of homeostasis also including autoimmune diseases, cancers, metabolic, dermatological, cardiovascular and neurodegenerative diseases.