Needle-shaped body with immiscible aqueous layers for low peeling strength
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Solution Overview
Problem
Existing needle-shaped bodies for transdermal administration face challenges in minimizing peeling strength between the projection and support base layers, leading to recognition issues after skin puncture, and inefficiencies in delivering agents due to incomplete skin penetration and residual medicine in the support base.
Innovation Solution
A method involving an intaglio plate with a recess, where a projection-side-layer aqueous solution and a support-base-side-layer aqueous solution form a liquid-liquid dispersion system, with the projection-side-layer having a higher specific gravity and containing pullulan or dextran, and the support-base-side-layer containing hydroxypropyl cellulose, hydroxyethyl cellulose, or methyl cellulose, ensuring a peeling strength of 8 N/15 mm or lower, allowing only the support base to peel from the skin while the projection remains in contact.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If the needle-shaped body is designed with both projection and support base layers, then the structural integrity is improved, but the peeling strength between layers becomes too high causing recognition after skin puncture
Solution Approach 1:
The patent applies different material compositions to different regions of the needle-shaped body. The projection side layer uses materials with lower peeling strength (e.g., pullulan, dextran) while the support base side layer uses materials with higher peeling strength (e.g., hydroxypropyl cellulose, hydroxyethyl cellulose). This local differentiation ensures the projection can easily peel from skin while the support base remains stable.
Solution Approach 2:
The needle-shaped body is segmented into two distinct layers: a projection side layer and a support base side layer. These layers are formed by separately supplying first and second aqueous solutions to the intaglio plate, allowing independent optimization of each layer's properties to achieve desired peeling characteristics.
2Ease of manufacture
If the needle-shaped body uses a single-layer structure, then the manufacturing process is simplified, but the delivery agent efficiency decreases due to incomplete penetration and residue in support base
Solution Approach 1:
The needle-shaped body is segmented into two distinct layers: a projection side layer and a support base side layer. These layers are formed by separately supplying first and second aqueous solutions to the intaglio plate, allowing independent optimization of each layer's properties to achieve desired peeling characteristics.
Solution Approach 2:
The patent applies different material compositions to different regions of the needle-shaped body. The projection side layer uses materials with lower peeling strength (e.g., pullulan, dextran) while the support base side layer uses materials with higher peeling strength (e.g., hydroxypropyl cellulose, hydroxyethyl cellulose). This local differentiation ensures the projection can easily peel from skin while the support base remains stable.
3Stability of the object's composition
If the peeling strength between projection and support base is increased, then the structural stability is improved, but the needle-shaped body cannot penetrate skin effectively
Solution Approach 1:
The patent applies different material compositions to different regions of the needle-shaped body. The projection side layer uses materials with lower peeling strength (e.g., pullulan, dextran) while the support base side layer uses materials with higher peeling strength (e.g., hydroxypropyl cellulose, hydroxyethyl cellulose). This local differentiation ensures the projection can easily peel from skin while the support base remains stable.
Solution Approach 2:
The needle-shaped body is segmented into two distinct layers: a projection side layer and a support base side layer. These layers are formed by separately supplying first and second aqueous solutions to the intaglio plate, allowing independent optimization of each layer's properties to achieve desired peeling characteristics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables efficient skin penetration with minimal recognition of the needle-shaped body post-puncture and ensures that the delivery agent is effectively introduced into the skin, reducing waste by confining it to the projection side layer.
Implementation Method 1
the first aqueous solution and the second aqueous solution are immiscible and form a liquid-liquid dispersion system
Implementation Method 2
the projection-side-layer has a higher specific gravity than the support-base-side-layer
Implementation Method 3
drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed
Data Source
AI summary
A method for manufacturing a needle-shaped body, including supplying a first aqueous solution to an intaglio plate, supplying a second aqueous solution to the intaglio plate, drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed on the intaglio plate, and separating the dried body from the intaglio plate such that a needle-shaped body including a needle-shaped projection and a support base which supports the needle-shaped projection is obtained. The intaglio plate includes a recess corresponding to the needle-shaped projection, the first aqueous solution is supplied to fill at least a portion of the recess, the first aqueous solution and the second aqueous solution are immiscible, the first aqueous solution forms a projection side layer in the needle-shaped body, and the second aqueous solution forms a support base side layer on the projection side layer in the needle-shaped body.