Immune Composition Modulating Th1/Th2 Ratios via Zinc Ascorbate
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Solution Overview
Problem
Current methods fail to balance immune system strengthening without causing hyperactivation or hypoactivation, and there is a need for compositions that effectively regulate Th1/Th2 and Treg/Th17 cell ratios, oxidative stress, and cytokine levels to address immune system imbalances.
Innovation Solution
A composition comprising zinc ascorbate, hesperidin, quercetin, L-arginine, and calcidiol, with specific dosage ranges, which can be administered in various forms, including dietary supplements and pharmaceutical formulations, to modulate immune cell functions and oxidative stress responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If immune system strengthening methods are applied, then immune system function is improved, but immune system hyperactivation or hypoactivation occurs
Solution Approach 1:
The patent applies parameter changes by precisely controlling the ratios and amounts of multiple immune-modulating ingredients (Th1-promoting ingredients like zinc and arginine, Th2-promoting ingredients like vitamin D and quercetin, Treg-promoting ingredients like probiotics) to achieve balanced immune regulation. The specific parameter ranges for each ingredient are optimized to prevent both hyperactivation and hypoactivation, resolving the contradiction between improving immune function and avoiding harmful imbalances.
Solution Approach 2:
The patent uses a composite formulation containing multiple types of ingredients that work synergistically: Th1-promoting ingredients (zinc, arginine), Th2-promoting ingredients (vitamin D, quercetin), Treg-promoting ingredients (probiotics), and antioxidant ingredients (vitamin C, resveratrol). This composite approach allows simultaneous modulation of different immune pathways to achieve balanced immune function without the harmful effects of single-ingredient approaches.
2Reliability
If Th1/Th2 and Treg/Th17 cell ratios are regulated, then immune system balance is improved, but complexity of composition increases
Solution Approach 1:
The patent segments the immune modulation function into distinct ingredient categories: Th1-promoting ingredients (zinc, arginine), Th2-promoting ingredients (vitamin D, quercetin), Treg-promoting ingredients (probiotics), and antioxidant ingredients (vitamin C, resveratrol). Each segment targets a specific immune pathway, making the complex regulation of Th1/Th2 and Treg/Th17 cell ratios manageable through modular ingredient selection and dosing.
Data Source
AI summary
The present disclosure relates to compositions as well as methods of use and methods of treating, including zinc ascorbate, hesperidin, quercetin, arginine, and calcidiol.