Automated Immunochemistry Analyzer On-Board Kitting
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current immunochemistry analysis systems are inefficient and slow due to the lack of capability to customize a mixture of multiple capture reagents, which limits the optimization of patient sample analysis for different types of analyte molecules.
Innovation Solution
An automated immunochemistry analyzer system that stores multiple capture reagents and paramagnetic particles, allowing users to select and mix combinations of capture reagents in situ, bind them to paramagnetic particles, and prepare custom analytical substrates for detecting immunogen-binding molecules in patient samples, enabling simultaneous preparation of substrates for various disease profiles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional immunochemistry analysis systems are used with fixed capture reagents, then the system structure is simple and easy to operate, but the analysis efficiency is low and cannot be customized for different analyte molecules
Solution Approach 1:
The system divides capture reagents into separate, individual reagents that can be independently selected and combined. Each capture reagent is stored separately in the refrigerator unit, and users can choose specific combinations based on the analyte molecules being tested, rather than using fixed pre-mixed reagents.
Solution Approach 2:
The automated immunochemistry analyzer is designed to perform multiple functions: storing multiple types of capture reagents and paramagnetic particles, mixing custom combinations, binding reactions, and optical analysis. This multi-functional system replaces multiple separate testing procedures with a single integrated platform.
2Manufacturing precision
If multiple separate tests are performed for different analyte molecules, then each test can be optimized individually, but the total testing time and number of required tests increases
Solution Approach 1:
The system combines multiple capture reagents into a single mixture that can simultaneously detect multiple analyte molecules. By mixing selected capture reagents with paramagnetic particles in one preparation step, the system performs what would otherwise require multiple separate tests, reducing total testing time while maintaining individual test optimization.
Solution Approach 2:
The system performs preliminary mixing and binding of multiple capture reagents with paramagnetic particles before the actual sample analysis. This pre-preparation of custom reagent mixtures allows the subsequent sample testing to proceed efficiently without requiring separate preparation steps for each analyte molecule.
3Adaptability or versatility
If custom mixtures of capture reagents are prepared manually, then the analysis can be optimized for specific analytes, but the operation becomes more complex and time-consuming
Solution Approach 1:
The automated immunochemistry analyzer performs the mixing and binding operations automatically once the user selects the desired capture reagents through the interface. The system self-manages the complex steps of mixing multiple reagents, binding them to paramagnetic particles, and preparing the custom mixture, eliminating the need for manual intervention in these technical steps.
Solution Approach 2:
The control unit acts as an intermediary between the user's selection and the physical mixing/binding processes. The user interface allows simple selection of desired analytes, and the control unit translates these selections into automated mixing and binding operations, bridging the gap between user-friendly operation and complex technical processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the efficiency and customization of diagnostic assays by allowing for the simultaneous preparation of multiple custom analytical substrates, improving the analysis of patient samples for different analyte molecules and reducing the number of required tests.
Implementation Method 1
mix together each capture reagent of the combination of two or more of the capture reagents; bind the mixture of the combination of two or more of the capture reagents to the paramagnetic particles
Implementation Method 2
automated immunochemistry analyzer storing a plurality of capture reagents and a plurality of paramagnetic particles
Data Source
Figure 1
Figure 2
Figure 3A~3C
AI summary
Methods and apparatus that mix a plurality of individual capture reagents for the diagnostic assays are described herein. In an embodiment, a system for optically analyzing a patient sample includes an automated immunochemistry analyzer storing a plurality of capture reagents and a plurality of paramagnetic particles, a user interface configured to allow a selection of a combination of two or more of the capture reagents, and a logic implementer configured to cause the automated immunochemistry analyzer to (i) mix together each capture reagent of the combination of two or more of the capture reagents; (ii) bind the mixture of the combination of two or more of the capture reagents to the paramagnetic particles; (iii) bind the patient sample to the bound mixture of the combination of two or more of the capture reagents; and (iv) optically analyze the patient sample.