Immunogenic Composition Modulating Immune Response for Bacterial Infections
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Solution Overview
Problem
Current treatments for severe infections, sepsis, and septic shock rely heavily on antimicrobial drugs, which, while effective in vitro, often fail to adequately engage the immune system in vivo, leading to inadequate immune responses and poor outcomes due to the lack of specificity and selectivity, resulting in significant morbidity and mortality.
Innovation Solution
Development of immunogenic compositions comprising Immunological Response Shifters (IRS) that include a combination of pathogen-associated molecular patterns (PAMPS), danger-associated molecular patterns (DAMPS), and stress response signals (SRS) to modulate the immune system, paired with antibiotics, to enhance the immune response and shift the host-pathogen equilibrium in favor of the host.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antimicrobial drugs are used to treat severe infections, then bacterial growth is inhibited, but the immune system is not adequately engaged, leading to inadequate immune responses
Solution Approach 1:
The patent introduces immunogenic compositions as intermediary substances that bridge the gap between antimicrobial drugs and the immune system. These compositions contain adjuvants and immunomodulators that actively engage and modulate the immune response, allowing the immune system to be adequately engaged during antimicrobial treatment without compromising the effectiveness of the antimicrobial drugs themselves.
Solution Approach 2:
The invention uses composite immunogenic compositions that combine multiple components including adjuvants, immunomodulators, and sometimes live attenuated viruses or bacteria. This composite approach creates a synergistic effect where the combination of substances provides both antimicrobial support and robust immune engagement, resolving the contradiction between relying on antimicrobials and needing active immune participation.
2Productivity
If antimicrobial drugs are used, then bacterial infections are treated, but side effects and lack of specificity increase morbidity
Solution Approach 1:
The patent applies local quality by using immunogenic compositions that can be administered locally at infection sites or through specific routes (intravenous, intramuscular, subcutaneous, oral, nasal, rectal, topical, or inhalation). This localized approach allows the immune modulation to occur precisely where needed, reducing systemic side effects while maintaining treatment effectiveness at the infection site.
Solution Approach 2:
The invention enables the immune system to be self-service by using immunogenic compositions that stimulate and modulate the body's own immune response. Rather than relying solely on external antimicrobial drugs with their inherent side effects, the composition activates the immune system's natural defense mechanisms, reducing dependence on pharmacological interventions and their associated harmful effects.
3Ease of operation
If the immune system is not adequately engaged, then treatment is simplified, but immune response is inadequate leading to poor outcomes
Solution Approach 1:
The patent employs preliminary action by administering immunogenic compositions before, during, or after antimicrobial treatment to prime or modulate the immune system in advance. The compositions contain adjuvants and immunomodulators that prepare the immune system to respond effectively when the infection is treated, ensuring adequate immune response without complicating the overall treatment protocol.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These compositions effectively reprogram the immune response from an ineffective to an effective adaptive response, reducing inflammation and promoting tissue regeneration, as demonstrated in clinical cases of sepsis and multi-resistant bacterial infections, offering a synergistic approach with antimicrobial drugs to improve treatment outcomes.
Implementation Method 1
comprising immunoactive antigenic agents presenting pathogen-associated molecular patterns (PAMPS) and/or danger associated molecular patterns (DAMPS) and/or stress response signals (SRS)
Data Source
AI summary
The present invention refers to pharmaceutical products comprising immunogenic compositions for modulating the immune system, which comprise a therapeutically effective amount of a Immunological Response Shifter (IRS) comprising two or more immunoactive antigenic agents presenting pathogen-associated molecular patterns (PAMPS) and/or danger associated molecular patterns (DAMPS) and/or Stress Response Signals (SRS), in association with an antibiotic and one or more physiologically acceptable carriers, excipients, diluents or solvents. IN other embodiments, the present invention refers to methods to treat severe bacterial infections, sepsis and modulating the immune system.