Immunological Peptide Sequence Embeddings for Immunity Status Prediction

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing technologies lack effective methods for evaluating and predicting immunological peptide sequences to determine immunity status, disease status, or vaccination status, particularly in assessing B cell and T cell responses.

Innovation Solution

Utilizing a language model to extract latent embeddings from immunological peptide sequences, which are then clustered and analyzed to predict immunity status, disease status, or vaccination status, and generate de novo peptide sequences with specific properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional methods are used to evaluate immunological peptide sequences, then the process is simple, but the prediction accuracy of immunity status, disease status, or vaccination status is insufficient

Engineering Contradiction:
Improveprediction accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent introduces language models as intermediary computational tools that process immunological peptide sequences through latent space embeddings. These language models act as mediators between raw sequence data and clinical predictions, enabling accurate classification of immunity status, disease status, and vaccination status without requiring complex manual analysis protocols

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces traditional mechanical and manual immunological evaluation methods with computational language model systems. Instead of physical laboratory procedures and manual sequence analysis, the system uses neural network-based language models to automatically extract features and predict immunological states, significantly improving accuracy while reducing operational complexity

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If comprehensive analysis of B cell and T cell receptor sequences is performed, then the immunological assessment is thorough, but the computational resources and time required increase

Engineering Contradiction:
Improveassessment reliabilityVSAvoidprocessing time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent performs preliminary action by pre-training language models on large corpora of immunological sequences before actual assessment. The models learn latent representations and patterns in advance, enabling rapid inference during actual clinical or research evaluation without requiring computationally intensive processing at the time of assessment

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent uses latent space embeddings as computational copies of the original peptide sequences. Instead of processing the full complexity of raw B cell and T cell receptor sequences during evaluation, the system works with compressed vector representations that capture essential immunological information, significantly reducing processing time while maintaining assessment reliability

Inventive Principle:
Principle #26Copying

Data Source

PatentUS20250329410A1Systems and Methods for Evaluating Immunological Peptide Sequences
Publication Date: 2025.10.23 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
  • US20250329410A1 patent drawing
  • US20250329410A1 patent drawing
  • US20250329410A1 patent drawing

AI summary

Systems and methods to assess peptide sequences can incorporate a language model to yield latent representations. Biological properties can be predicted based on latent representations of peptide sequences. Systems and methods to assess immunity status can incorporate one or more models and classifiers to predict health status. Various systems and methods can predict whether an individual is having an active immunological response. Various systems and methods can predict whether an individual is having or has had a particular type of immunological response, such as a pathogenic infection, vaccination, or immunological disorder.