Immunonutritional Compositions for Bone Marrow Toxicity Mitigation
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Solution Overview
Problem
Anti-cancer therapies induce myelosuppression and immunosuppression, impairing the immune system's ability to effectively target tumor cells during treatment, and existing immunotherapies are insufficient in mitigating these side effects and enhancing immune response.
Innovation Solution
Administration of immunonutritional compositions containing immuno-enhancing agents such as probiotics, amino acids, nucleotides, and fatty acids to cancer patients undergoing anti-cancer therapy, which enhance innate and adaptive immune responses and preserve immune cell function, thereby complementing anti-cancer treatments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If anti-cancer therapies (chemotherapy/radiotherapy) are administered to eliminate tumor cells, then tumor cell death is achieved, but bone marrow toxicity and immunosuppression occur
Solution Approach 1:
The patent applies preliminary anti-action by administering immunonutritional compositions containing probiotics, amino acids, nucleotides, and fatty acids before and during anti-cancer therapy to preemptively protect immune cells from therapy-induced damage. This pre-conditioning of the immune system with nutritional support prevents the severe immunosuppression that would otherwise occur during chemotherapy or radiotherapy, allowing the immune system to maintain functionality while tumor cells are eliminated.
2Productivity
If high doses of anti-cancer therapy are used to maximize tumor cell killing, then treatment efficacy increases, but bone marrow suppression and immune impairment worsen
Solution Approach 1:
The patent converts the harmful effect of therapy-induced immune suppression into a benefit by using the immunonutritional composition to stimulate and enhance immune cell function. The probiotics, amino acids, nucleotides, and fatty acids in the composition are converted from mere nutritional supplements into active immunomodulators that transform the suppressed immune state into an enhanced anti-tumor immune response, allowing higher therapy doses to be tolerated.
3Reliability
If immunotherapy is added to enhance immune response during anti-cancer therapy, then immune function improves, but treatment complexity increases
Solution Approach 1:
The patent applies universality by designing an immunonutritional composition that simultaneously provides multiple functions: probiotics for gut immunity and immune modulation, amino acids for immune cell proliferation and protein synthesis, nucleotides for nucleic acid synthesis in dividing immune cells, and fatty acids for membrane integrity and anti-inflammatory effects. This single multi-functional nutritional intervention replaces the need for multiple separate immunotherapeutic agents, simplifying the treatment regimen while maintaining enhanced immune response.
Data Source
AI summary
The present invention relates to methods and immunonutritional compositions for preventing or mitigating paralysis of the bone marrow, caused by a tumor or neoplasm, between cycles of and after anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject tumor-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to treatment; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened due to paralysis of the bone marrow, caused by a tumor or neoplasm.