Impedance Sensor Probe for Real-Time Lesion Boundary Detection
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Solution Overview
Problem
Current monitoring techniques for focal ablation and cell membrane disruption therapies lack precision in determining the extent of treatment within tissues, often resulting in imprecise procedures and potential side effects due to reliance on bulk tissue properties rather than specific measurements at well-defined points.
Innovation Solution
The development of an electrical conductivity sensor system capable of measuring both low-frequency and high-frequency impedance, integrated with a probe that can be used to monitor tissue characteristics in real-time, allowing for precise detection of the lesion or treated area front and automatic adjustment of treatment protocols.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If bulk tissue properties are used for monitoring, then the monitoring coverage is extensive, but the measurement precision is insufficient
Solution Approach 1:
The patent divides the monitoring function into multiple discrete impedance sensors positioned at specific locations within the treatment probe. Each sensor measures impedance at its local position, transforming a single bulk measurement into multiple localized measurements. This segmentation enables precise determination of the treated area front by comparing impedance changes across different sensor locations, directly resolving the contradiction between measurement precision and device complexity.
Solution Approach 2:
The patent implements local quality by placing impedance sensors at specific positions within the probe to measure tissue properties at well-defined points rather than relying on bulk tissue properties. The sensors are strategically positioned to detect the treated area front, providing localized measurement data that improves precision while maintaining manageable device complexity through targeted sensing locations.
2Reliability
If real-time monitoring is implemented, then the treatment control is improved, but the system complexity increases
Solution Approach 1:
The patent implements real-time feedback by continuously monitoring impedance changes at multiple sensor locations and using this information to determine the treated area front position. The system provides immediate feedback during treatment, allowing dynamic adjustment of treatment parameters to maintain reliable control. This feedback mechanism improves treatment control reliability while managing system complexity through efficient real-time processing of impedance data.
Solution Approach 2:
The treatment probe is designed with multi-functionality, integrating both treatment delivery capabilities and real-time monitoring functions into a single device. The impedance sensors are incorporated within the same probe structure that delivers treatment, allowing simultaneous treatment and monitoring without requiring separate complex systems. This universal design improves treatment control while minimizing additional system complexity.
3Measurement precision
If multiple impedance sensors are used, then the detection accuracy is improved, but the manufacturing complexity increases
Solution Approach 1:
The patent employs a nested structure where multiple impedance sensors are integrated within the probe housing in a compact arrangement. The sensors are positioned concentrically or in a nested configuration that maximizes spatial efficiency. This nesting approach enables the inclusion of multiple sensors for improved detection accuracy while simplifying manufacturing by reducing the overall device footprint and minimizing assembly complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system enables real-time monitoring and control of focal ablation or cell membrane disruption therapies, improving specificity and minimizing side effects by accurately determining the position and size of the treated area within tissues.
Implementation Method 1
the impedance sensor can be configured to measure a low-frequency and a high-frequency impedance
Data Source
AI summary
Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.