Implantable Analyte Sensor Verification via Square-Wave Calibration

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing continuous glucose monitoring systems face inaccuracies due to electrode passivation, enzyme activity attenuation, and enzyme and electronic medium loss, leading to performance differences between sensors and inconsistent calibration results.

Innovation Solution

A method involving outputting a square wave signal to an implanted detecting device, receiving a current signal, and generating a calibration curve to perform personalized calibration and verification based on the correspondence between the signal and current, considering performance differences between devices.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If experience curve calibration is used for all sensors, then calibration process is simplified, but measurement precision deteriorates due to performance differences between sensors

Engineering Contradiction:

Improvecalibration process complexityVSAvoidblood glucose testing accuracy

Core Design Contradiction:

Device complexityVSMeasurement precision

Solution Approach 1:

The patent applies preliminary action by performing calibration testing on each sensor before implantation. The sensor is calibrated in advance using a calibration solution, and the calibration parameters (slope and intercept) are stored in the sensor's memory. This preliminary calibration ensures that each sensor's unique characteristics are captured before actual use, resolving the contradiction between simplified calibration process and accurate measurement.

Inventive Principle:

Principle #10Preliminary action

2Productivity

If sensors are used long-term for continuous monitoring, then productivity is improved, but reliability deteriorates due to electrode passivation and enzyme activity attenuation

Engineering Contradiction:

Improvecontinuous monitoring capabilityVSAvoidsensor accuracy over time

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent implements feedback by continuously monitoring the sensor's electrical parameters (impedance, capacitance, resistance) and comparing them against reference values. When deviations indicate sensor degradation from electrode passivation or enzyme activity attenuation, the system triggers recalibration or alerts the user. This feedback mechanism maintains reliability during long-term continuous monitoring by detecting and correcting drift in sensor performance.

Inventive Principle:

Principle #23Feedback

3Adaptability or versatility

If sensor sensitivity changes over time, then adaptability to long-term use is improved, but measurement precision deteriorates due to unaccounted sensitivity drift

Engineering Contradiction:

Improvelong-term operation capabilityVSAvoidanalyte detection accuracy

Core Design Contradiction:

Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The patent applies periodic action by implementing regular calibration cycles during the sensor's operational life. The system periodically applies calibration solutions and recalibrates the sensor parameters (slope and intercept) to account for sensitivity changes over time. This periodic recalibration maintains measurement precision while allowing the sensor to operate adaptively over extended periods, resolving the contradiction between long-term adaptability and accurate measurement.

Inventive Principle:

Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for more accurate analyte concentration detection by the implanted device, reducing errors and improving stability by accounting for individual device performance variations.

Implementation Method 1

outputting a square wave signal to an implantable detecting device that has been implanted into a subject, where the implantable detecting device is configured to detect a concentration of an analyte in the subject, and a potential of the square wave signal increases incrementally over time; receiving a first current signal produced by the implantable detecting device in response to the square wave signal

Methodology Applied

Scientific EffectElectrochemical reaction: Redox Reactions

Data Source

PatentUS20260102090A1Method for calibrating and verifying implantable detecting device, implantable detecting device, apparatus, and electronic device

Publication Date: 2026.04.16 SHENZHEN GOODIX TECH CO LTD

AI summary

A method for calibrating and/or verifying an implantable detecting device, an implantable detecting device, an apparatus, and an electronic device are provided. The method includes: outputting a square wave signal to an implantable detecting device that has been implanted into a subject, where the implantable detecting device is configured to detect a concentration of an analyte in the subject, and a potential of the square wave signal increases incrementally over time; receiving a first current signal produced by the implantable detecting device in response to the square wave signal; generating a calibration curve based on a correspondence between the first current signal and the square wave signal; and performing calibration and/or functional verification on the implantable detecting device based on the calibration curve.