Implantable Repository for Local Bioactive Agent Delivery
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Solution Overview
Problem
Current methods for attaching bioactive agents to medical devices are complex and costly, limiting their application to only specific devices and not allowing for widespread local delivery to tissue sites during surgical procedures.
Innovation Solution
An implantable repository with a housing containing a bioactive agent and an attachment member, designed to be coupled to medical devices or tissue surfaces, allowing for secure deposition and attachment using wound closure devices such as fasteners or sutures, enabling broad tissue coverage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bioactive agents are attached to medical devices using surface modification methods, then local delivery of bioactive agents is achieved, but the process becomes complicated and costly
Solution Approach 1:
The system separates the bioactive agent delivery function from the medical device itself by using independent implantable repositories that can be attached to various devices. This segmentation allows the bioactive agent to be delivered locally without complicating the medical device manufacturing process, as the repository is a separate, standardized component.
Solution Approach 2:
The implantable repository acts as an intermediary carrier between the medical device and the bioactive agent. Instead of directly attaching the bioactive agent to the medical device through complex surface modification, the repository serves as a simple attachment platform that holds the bioactive agent and can be easily coupled to the medical device using standard attachment members.
2Reliability
If bioactive agents are coated on specific medical devices, then local delivery is achieved for those devices, but other devices at the tissue site cannot benefit from local delivery
Solution Approach 1:
The implantable repository is designed as a universal platform that can be attached to multiple types of medical devices through standardized attachment members. This allows a single repository design to serve multiple functions across different surgical procedures and device types, enabling broad adaptability while maintaining reliable local delivery of bioactive agents.
3Reliability
If surface modification methods are used to attach bioactive agents, then bioactive agents can be applied as coating, but the process is costly
Solution Approach 1:
The implantable repository is designed as a disposable, pre-loaded carrier that eliminates the need for expensive surface modification processes. The repository can be manufactured independently with the bioactive agent already incorporated, then attached to medical devices as a complete unit, significantly reducing manufacturing costs compared to custom surface modification of each medical device.
Data Source
AI summary
The present disclosure is directed to an implantable repository including a housing comprising at least one bioactive agent and at least one attachment member coupled to the housing, the at least one attachment member configured to couple the implantable repository to at least one of a medical device and a tissue surface.