Implantable Analyte Sensor With Integrated ASIC Circuitry
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Solution Overview
Problem
Individuals with diabetes often fail to monitor their glucose levels frequently due to convenience, pain, and cost issues associated with existing glucose monitoring devices, which affects glycemic control.
Innovation Solution
Development of devices and systems that include application-specific integrated circuits (ASICs) for electrical coupling with electrochemical sensors, enabling continuous in vivo monitoring of glucose levels, with features like wireless communication and reduced pain, cost-effectiveness, and discreet monitoring.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If continuous in vivo glucose monitoring is implemented, then measurement precision and glycemic control improvement are enhanced, but device complexity and manufacturing cost increase
Solution Approach 1:
The patent combines the sensor element, ASIC electronics, and housing into a single integrated implantable device. The sensor and electronics are merged into one unit that can be implanted together, eliminating the need for separate components and reducing overall system complexity despite maintaining high measurement precision through continuous monitoring.
Solution Approach 2:
The device performs multiple functions within a single implantable unit: it continuously monitors glucose levels, processes the electrochemical signals through integrated ASIC circuitry, stores data, and communicates with external devices. This multi-functionality reduces the need for multiple separate devices while maintaining measurement accuracy.
2Measurement precision
If frequent glucose monitoring is performed, then glycemic control improves, but pain and convenience issues increase
Solution Approach 1:
The patent replaces the mechanical puncture-based glucose testing system with an electrochemical sensor that continuously monitors glucose through the skin or interstitial fluid. This substitution eliminates the repeated needle sticks and manual blood sampling, allowing frequent monitoring without additional pain or inconvenience to the user.
Solution Approach 2:
The implantable sensor performs automatic continuous monitoring without requiring user intervention for each measurement. The device self-regulates the monitoring process, eliminating the need for users to manually initiate tests and reducing the association between monitoring frequency and user discomfort.
3Device complexity
If implantable sensor electronics are integrated, then device complexity is reduced, but manufacturing precision requirements increase
Solution Approach 1:
The patent integrates the sensor and ASIC electronics into a pre-assembled implantable unit before implantation. This preliminary integration allows for controlled manufacturing conditions where precise alignment and bonding can be achieved during fabrication, rather than attempting to integrate components after implantation, thereby managing precision requirements during the manufacturing process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution encourages frequent glucose monitoring by providing a convenient, cost-effective, and minimally invasive method for continuous glucose tracking, improving glycemic control and user adherence.
Implementation Method 1
application specific integrated circuit (ASIC) configurations that provide electrical coupling with electrochemical sensors such as, for example, in vivo glucose sensors for continuous monitoring of analytes such as glucose
Data Source
AI summary
Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.