Implantable Sensor Holder Sealing for Continuous Glucose Monitoring
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Solution Overview
Problem
Patients with chronic conditions face discomfort due to frequent blood draws for monitoring physiological parameters like blood glucose, and existing methods are insufficient for providing accurate, real-time data for medical treatment.
Innovation Solution
A thin physiological signal monitoring device designed for long-term implantation under the skin, featuring a sensor with a signal detection end and output end, a transmitter, and a holder with an implantation hole, fixing indentation, filler, and blocking element for stable and waterproof sealing, allowing for real-time monitoring of physiological signals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional blood glucose measurement using test strip and glucose meter is used, then blood glucose level can be obtained, but patients must experience repeated blood collections which causes discomfort
Solution Approach 1:
The patent replaces the mechanical blood collection and test strip insertion system with a miniaturized implantable sensor that directly contacts interstitial fluid through a microneedle array, eliminating the need for repeated finger pricks and test strip handling while maintaining measurement capability
Solution Approach 2:
The implantable sensor system performs self-service by continuously monitoring interstitial fluid glucose levels without requiring patient intervention for sample collection, with the sensor automatically detecting and transmitting physiological data
2Loss of time
If instantaneous blood glucose value is used for medication basis, then measurement is quick, but it is insufficient for patients with unstable blood glucose level
Solution Approach 1:
The patent implements continuous monitoring of interstitial fluid glucose levels through the implantable sensor, providing a time-series dataset that captures glucose trends and patterns, enabling more accurate medication decisions compared to discrete instantaneous measurements
3Duration of action of stationary object
If small sensing elements are implanted in subcutaneous tissue for long time, then real-time physiological data monitoring can be provided, but the device structure becomes complex
Solution Approach 1:
The patent employs a nested structure where multiple microneedle sensors are integrated within a single implantable holder unit, allowing complex sensing functionality to be packaged in a compact form that simplifies the overall implantation procedure and device architecture
Solution Approach 2:
The sensor system is segmented into modular components including the implantable holder with microneedle array and the external reader device, allowing the complex functionality to be distributed across separate units that interact wirelessly, simplifying each individual component's design
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides stable and continuous monitoring of physiological signals, reducing patient discomfort and enabling accurate real-time data collection, while preventing external liquids from entering and blood from leaking through the implantation site.
Implementation Method 1
the level of the blood glucose is obtained by measuring the magnitude of current generated by the reaction between the glucose in the blood and glucose oxidase in the test strip
Data Source
AI summary
The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.