Implantable Analyte Sensor Calibration Using Incremental Square Waves
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Solution Overview
Problem
Existing continuous glucose monitoring systems face inaccuracies due to electrode passivation, enzyme activity attenuation, and enzyme and electronic medium loss, leading to performance differences between sensors and inconsistent calibration results.
Innovation Solution
A method involving outputting a square wave signal to an implanted detecting device, receiving a current signal, and generating a calibration curve to perform personalized calibration and verification based on the correspondence between the signals, considering performance differences between devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If a continuous glucose monitoring system is used for long-term monitoring, then the monitoring duration is extended, but sensor sensitivity changes due to electrode passivation, enzyme activity attenuation, and functional film layer expansion, leading to inaccurate detection results
Solution Approach 1:
The patent applies preliminary action by performing calibration tests on sensors during the production process to establish experience curves that predict sensitivity changes over time. These curves are pre-calculated and stored in the monitoring system, allowing the system to proactively compensate for expected sensor degradation during long-term monitoring without requiring real-time adjustments.
Solution Approach 2:
The patent utilizes parameter changes by dynamically adjusting the sensitivity parameter of the sensor based on the experience curve. The system retrieves the appropriate sensitivity correction factor from the pre-established experience curve corresponding to the current monitoring time point, and applies this factor to compensate for sensor degradation, thereby maintaining detection accuracy throughout the monitoring period.
2Extent of automation
If experience curves are used to calibrate sensors, then calibration is automated, but performance differences between individual sensors result in relatively large errors in blood glucose testing results
Solution Approach 1:
The patent applies local quality by transitioning from a universal experience curve applicable to all sensors to sensor-specific calibration curves. Each sensor undergoes individual calibration testing during production, generating a unique experience curve that reflects its specific performance characteristics. This localized approach accounts for manufacturing variations and ensures that each sensor is calibrated according to its own behavioral pattern, thereby improving calibration accuracy while maintaining automation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for more accurate analyte concentration detection by considering device-specific variations, reducing errors, and ensuring stable operation of the implantable detecting device.
Implementation Method 1
an implantable detecting device, which is configured to detect a concentration of an analyte in the subject
Implementation Method 2
outputting a square wave signal to an implantable detecting device... where the implantable detecting device is configured to detect a concentration of an analyte in the subject, and a potential of the square wave signal increases incrementally over time
Data Source
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AI summary
A method for calibrating and/or verifying an implantable detecting device and an implantable detecting device are provided. The method includes: outputting a square wave signal to an implantable detecting device that has been implanted into a subject, where the implantable detecting device is configured to detect a concentration of an analyte in the subject, and a potential of the square wave signal increases incrementally over time; receiving a first current signal produced by the implantable detecting device in response to the square wave signal; generating a calibration curve based on a correspondence between the first current signal and the square wave signal; and performing calibration and/or functional verification on the implantable detecting device based on the calibration curve.