In Vivo Photon Analysis System for Deep Tissue Diagnosis

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Solution Overview

Problem

Current photon diagnosis and therapy technologies are limited by the inability of visible and near-infrared light to penetrate deep into human tissues, restricting diagnosis and therapy to body surfaces and larger cavities, necessitating a method to access deeper lesions without causing significant harm.

Innovation Solution

An in vivo photon analysis system and method utilizing an in vivo device with an intervention function module to enter the body, coupled with an in vitro device featuring a laser light source module, analyzing and testing module, and coupling and switching module to output and analyze laser light of multiple wavelengths, enabling deep tissue penetration and feedback fluorescence analysis for diagnosis and therapy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Length of moving object

If visible light and near-infrared light are used for photon diagnosis and therapy, then the technology can be implemented with current devices, but the light cannot penetrate deep into human tissues, restricting diagnosis and therapy to body surfaces and larger cavities

Engineering Contradiction:
Improvepenetration depth into tissueVSAvoidtissue damage
Core Design Contradiction:
Length of moving objectVSObject-affected harmful factors

Solution Approach 1:

The patent introduces an intermediary substance (contrast agent or photosensitizer) that mediates between the laser light and deep tissue. This intermediary absorbs the laser energy and converts it to fluorescence or other detectable signals, enabling deep tissue penetration without direct laser damage to the tissue. The intermediary acts as a bridge that allows energy transfer from the laser to the target tissue at depth without causing harmful effects.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the parameter of light wavelength by using multiple wavelengths of laser light (not just visible or near-infrared). By selecting specific wavelengths that correspond to absorption peaks of contrast agents or photosensitizers, the system achieves deep tissue penetration. The parameter change from standard visible/NIR wavelengths to specific wavelengths optimized for tissue penetration and contrast agent absorption enables the solution.

Inventive Principle:
Principle #35Parameter changes

2Length of moving object

If multiple wavelengths of laser light are used to penetrate deep tissue and analyze feedback fluorescence, then deep tissue diagnosis and therapy can be achieved, but the device complexity increases with multiple laser sources and coupling modules

Engineering Contradiction:
Improvepenetration depth into tissueVSAvoiddevice structure
Core Design Contradiction:
Length of moving objectVSDevice complexity

Solution Approach 1:

The patent makes the laser light source module universal by enabling it to output multiple wavelengths of laser light. Instead of requiring separate laser sources for different wavelengths, a single multi-wavelength laser source performs all the functions. The coupling and switching module also serves multiple purposes: coupling different laser wavelengths, switching between them, and directing them to the appropriate targets. This multi-functionality reduces the overall number of components needed.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges multiple laser light sources into a single integrated laser light source module that can output multiple wavelengths. It combines the coupling and switching functions into a single module that handles both tasks. By merging these separate components, the system achieves the same functionality with fewer discrete parts, reducing device complexity while maintaining the capability to penetrate deep tissue with multiple wavelengths.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables minimally invasive deep tissue penetration and analysis, allowing for effective diagnosis and therapy of internal lesions while minimizing tissue damage, facilitating early pathology detection and treatment.

Implementation Method 1

a laser light source module, configured to output a first group of laser and a second group of laser

Methodology Applied
Scientific EffectLaser: Laser

Implementation Method 2

visible lights and near-infrared lights cannot penetrate deep into human tissues

Methodology Applied
Scientific EffectLight penetration: Light

Implementation Method 3

acquire a feedback fluorescence of the preset position; receive the feedback fluorescence, and analyze the feedback fluorescence

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentUS10588514B1Vivo photon analysis system and method
Publication Date: 2020.03.17 SHANG HUA
  • US10588514B1 patent drawing
  • US10588514B1 patent drawing

AI summary

The present invention provides an in vivo photon analysis system and method, wherein the system comprises: an in vivo device and an in vitro device; the in vivo device comprises: an intervention function module which enters into a human body, outputs a laser output by the in vitro device to a preset position, and acquires a feedback fluorescence of the preset position; the in vitro device comprises: a laser light source module which outputs a first group of laser and a second group of laser; a coupling and switching module which couples the first group of laser to obtain a first to-be-output laser, couples the second group of laser to obtain a second to-be-output laser, acquires the feedback fluorescence, and sends the feedback fluorescence to an analyzing and testing module; an analyzing and testing module which receives the feedback fluorescence, and analyzes the feedback fluorescence, so as to obtain analysis results of the feedback fluorescence, and send the analysis results of the feedback fluorescence to a core processing module; and a core processing module which controls the laser light source module to output the first group of laser, and controls the laser light source module to output the second group of laser according to the analysis results of the feedback fluorescence.