Indaziflam Crystalline Form With Improved Powder Flowability

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Solution Overview

Problem

Existing methods for preparing indaziflam do not provide a crystalline form with improved flowability, which is crucial for manufacturing efficiency and product quality in solid processing industries.

Innovation Solution

A novel crystalline form of indaziflam with a compressibility index lower than or equal to 17 is achieved through recrystallization in specific solvents, such as alcohols, alcohols mixed with water, amides, lactams, and esters of carboxylic acids, followed by pulverization and mixing with inert additives.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If conventional preparation methods are used, then the manufacturing process is simple, but the flowability is poor causing capacity shortfall and production interruptions

Engineering Contradiction:

ImproveflowabilityVSAvoidmanufacturing efficiency

Core Design Contradiction:

Ease of operationVSProductivity

Solution Approach 1:

The patent changes the physical state parameter of indaziflam from amorphous to crystalline form through controlled recrystallization processes, achieving improved flowability (compressibility index ≤17) while maintaining manufacturing efficiency

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent utilizes phase transition from amorphous to crystalline state through recrystallization in specific solvents (alcohols, amides, lactams, esters), transforming the material's physical properties to achieve better flowability without compromising productivity

Inventive Principle:

Principle #36Phase transitions

2Ease of operation

If recrystallization in specific solvents is performed, then the flowability is improved, but the preparation process becomes more complex

Engineering Contradiction:

ImproveflowabilityVSAvoidpreparation process complexity

Core Design Contradiction:

Ease of operationVSDevice complexity

Solution Approach 1:

The patent systematically changes solvent parameters (selecting from specific groups: alcohols, amides, lactams, esters) to achieve crystallization with improved flowability, managing process complexity through structured solvent selection criteria

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces solvent intermediaries (recrystallization solvents) that facilitate the transformation from amorphous to crystalline form, improving flowability while the solvent acts as a temporary medium that can be removed in subsequent processing steps

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The novel crystalline form exhibits higher flowability, reducing capacity shortfall and production interruptions, and enhancing manufacturing efficiency.

Implementation Method 1

indaziflam is recrystallized in a solvent selected from the group consisting of alcohols, alcohols mixed with water, amides, lactams, esters of carboxylic acids

Methodology Applied

Scientific EffectRecrystallization: Crystallisation

Data Source

PatentUS20250382272A1Crystalline form of indaziflam, methods for its preparation and use thereof

Publication Date: 2025.12.18 ADAMA AGAN LTD

AI summary

A crystalline form of indaziflam, processes for the preparation thereof, an agrochemical composition containing the crystalline form of indaziflam and a process for the preparation of the agrochemical composition.