Target-Controlled Infusion Induction Dose Conversion
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Solution Overview
Problem
Physicians are often more familiar with manual infusion operations and may struggle to define a target concentration for drug administration using target-controlled infusion protocols, which can complicate the initiation of automatic drug administration systems.
Innovation Solution
A system and method that allow for intuitive control of target-controlled infusion protocols by calculating a drug concentration based on a user-specified induction dose, enabling the automatic control of infusion operations while considering prior manual induction doses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If target-controlled infusion protocol is used to achieve automatic drug administration control, then automation extent is improved, but ease of operation deteriorates because physicians are not familiar with defining target concentrations
Solution Approach 1:
The system introduces an intermediary conversion mechanism that translates the physician's familiar manual induction dose parameters into the mathematical model's required target concentration parameters. The control device automatically calculates the target concentration based on the induction dose, serving as a mediator between the physician's expertise and the automated system's requirements.
Solution Approach 2:
The system changes the parameter representation from the physician's familiar induction dose parameters (dose amount, administration time) into the mathematical model's target concentration parameters (concentration values, time profiles). This parameter transformation allows the system to maintain automation while being operable by physicians with traditional training.
2Manufacturing precision
If mathematical model is used to calculate drug concentration based on induction dose, then manufacturing precision is improved, but device complexity increases
Solution Approach 1:
The control device is pre-configured with the mathematical model that describes drug distribution in the patient's body. This preliminary preparation of the mathematical model allows the system to accurately calculate target concentrations without requiring complex real-time computations or sophisticated algorithms during actual operation.
Solution Approach 2:
The mathematical model automatically performs the concentration calculation based on the induction dose parameters provided by the physician. The system serves itself by using the input parameters (induction dose, administration time) to generate the required control parameters (target concentration, infusion rate) through the pre-programmed mathematical relationships.
Data Source
AI summary
A system for controlling a target-controlled infusion for administering a drug to a patient (P), comprises at least one infusion device (31-33) for administering a drug to the patient (P), and a control device (2) which is configured to control operation of the at least one infusion device (31-33) in order to establish a drug concentration within the patient (P) based on a target concentration (CT), wherein the control device (2) is configured to execute a target-controlled infusion protocol using a mathematical model modelling a drug distribution in the patient's body for controlling operation of the at least one infusion device (31-33). The control device (2) is configured to calculate, based on a user-specified induction dose (I), a value of a drug concentration within the patient (P) using said mathematical model and to consider said value of the drug concentration at the start of execution of said target-controlled infusion protocol.