Inductive Pulse Burst Treatment for Inflammation Modulation
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Solution Overview
Problem
Sub-threshold inductive neuromodulation devices such as PEMF and LFMS struggle to reproducibly achieve a robust reduction in inflammation, with existing commercially available devices often operating outside the critical ranges for effective inflammatory response modulation.
Innovation Solution
The application of pulsed electromagnetic field (PEMF) energy with specific parameters, including a duty cycle of 4% or greater and an amplitude between 0.2 G and 1 G, is used to reduce inflammation by targeting cytokines and chemokines like TNF-α, MIP1a, IL-1β, IP-10, and MCP-1, while higher amplitude and duty cycle combinations increase inflammatory responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If PEMF devices operate outside critical parameter ranges (higher amplitude/duty cycle), then device complexity is reduced and ease of operation is improved, but the reliability of inflammatory response modulation deteriorates
Solution Approach 1:
The patent applies parameter changes by precisely controlling PEMF amplitude (0.2-1.0 G) and duty cycle (4-20%) to achieve reliable anti-inflammatory effects. This resolves the contradiction by establishing specific parameter ranges that ensure consistent inflammatory response modulation while maintaining operational simplicity through standardized protocols.
2Ease of operation
If PEMF amplitude and duty cycle are increased, then ease of operation is improved, but the harmful effects increase due to increased inflammatory response
Solution Approach 1:
The patent applies preliminary anti-action by pre-establishing safe parameter boundaries (amplitude ≤1.0 G, duty cycle ≤20%) that prevent excessive inflammatory responses before treatment begins. This resolves the contradiction by allowing operational simplicity while preemptively avoiding harmful effects through constrained parameter selection.
3Adaptability or versatility
If sub-threshold field strengths are used to treat large tissue areas, then ease of operation is improved, but the reliability of targeting specific regions deteriorates
Solution Approach 1:
The patent applies local quality by using larger coils for broad coverage while maintaining precise control over electromagnetic field parameters (amplitude 0.2-1.0 G, duty cycle 4-20%) to achieve reliable anti-inflammatory effects in specific target regions. This resolves the contradiction by allowing versatile area coverage while ensuring precise therapeutic action through standardized parameter application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach results in a significant reduction of 20% or more in inflammatory markers, providing a robust and reliable method for modulating inflammation, and can be used to treat various inflammatory disorders and conditions, including those associated with SARS-CoV-2 infections.
Implementation Method 1
Inductive neuromodulation typically involves generating an electromagnetic field by passing current through an antenna (e.g., coil), and applying the resulting electromagnetic field to non-invasively modulate the activity of nervous system tissue adjacent to the antenna
Data Source
AI summary
Apparatuses and methods for delivery of pulsed electromagnetic field (PEMF) energy therapy to modulate inflammation using high-frequency current pulsed through one or more coils. For example, described herein are pulse burst waveforms, coil applicators for the head and body, and implantable biocompatible coil arrays. The methods and apparatuses described herein include parameters for PEMF energy that specifically and robustly reduce an inflammatory response. Also described herein are methods and apparatuses increasing an inflammatory response using PEMF parameters that specifically and robustly increase in inflammatory response.