Indwelling Glucose Sensor Potential Cycling for Faster Stabilization
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Solution Overview
Problem
Continuous glucose monitoring sensors require a lengthy run-in time after insertion, leading to unreliable initial measurements, especially in critical situations, and are susceptible to baseline drift and spurious signals.
Innovation Solution
A method of preconditioning glucose sensors by cyclically applying varying potentials to reduce run-in time, involving in vivo or in vitro conditioning, where the sensor is cycled between two different potentials until a stable current ratio or differential is achieved, typically between 650 mV and 850 mV, to ensure accurate and stable glucose readings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a sensor is inserted into tissue to measure glucose continuously, then continuous monitoring capability is achieved, but the sensor requires a lengthy run-in time during which measurements are unreliable
Solution Approach 1:
The sensor is preconditioned by cycling between two different potentials (e.g., 650 mV and 850 mV) before actual glucose measurements begin. This preliminary action stabilizes the sensor response and reduces the run-in time required for reliable measurements.
Solution Approach 2:
The sensor undergoes periodic potential cycling during the preconditioning phase, alternating between two different potentials to accelerate stabilization. This periodic application of different potentials helps achieve reliable measurements faster than continuous single-potential operation.
2Loss of time
If the sensor operates immediately after insertion, then run-in time is reduced, but measurement accuracy and stability deteriorate due to baseline drift and spurious signals
Solution Approach 1:
The sensor is preconditioned by cycling between two different potentials (e.g., 650 mV and 850 mV) before actual glucose measurements begin. This preliminary action stabilizes the sensor response and reduces the run-in time required for reliable measurements.
Solution Approach 2:
The patent replaces the traditional time-based stabilization approach with an electrochemical conditioning approach using potential cycling. Instead of waiting passively for the sensor to stabilize over time, active electrochemical conditioning is applied to achieve rapid stabilization.
3Device complexity
If the sensor is conditioned using traditional single-potential stabilization, then the process is simple, but baseline drift and spurious signals persist
Solution Approach 1:
The sensor undergoes periodic potential cycling during the preconditioning phase, alternating between two different potentials to accelerate stabilization. This periodic application of different potentials helps achieve reliable measurements faster than continuous single-potential operation.
Solution Approach 2:
The patent changes the electrochemical parameter (applied potential) dynamically during conditioning, cycling between two different potentials rather than maintaining a constant potential. This parameter variation enhances stabilization effectiveness and reduces baseline drift.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly reduces the run-in time to under an hour, enhances sensor stability, and improves accuracy by minimizing baseline drift and spurious signals, allowing for immediate and reliable glucose monitoring.
Implementation Method 1
measuring a first current at a first applied potential... measuring a second current at a second applied potential
Data Source
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AI summary
A method of in vivo conditioning of an indwelling sensor to reduce run-in time, (stabilization time) comprising: a) applying a first potential to the sensor and measuring a first current at the first potential; b) applying a second potential to the sensor and measuring a second current at the second potential; c) determining a relationship of the first current measured to the second current measured; repeating a, b, and c until the relationship between the first current measured and the second current measured has stabilized, thereby reducing sensor run-in time.