Infant Communication Marker Set for Breast Milk Evaluation

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Solution Overview

Problem

Current methods lack an effective and efficient way to evaluate the development of an infant's communication ability based on nutritional factors, particularly in breast milk composition, which varies significantly among lactating women of different races and dietary patterns, making it challenging to provide timely nutritional interventions.

Innovation Solution

A marker set comprising specific fatty acids (C18:3n6, C18:2n6t, C20:3n3, C18:3n3, C18:2n6c, C20:4n6, C20:3n6, C22:6n3, C20:5n3) is used, with a method involving sample collection, pretreatment, gas chromatography-mass spectrometry analysis, and a scoring system to assess communication ability development.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If comprehensive nutritional evaluation methods are used to assess infant communication ability development, then evaluation accuracy is improved, but evaluation complexity and cost increase

Engineering Contradiction:
Improveevaluation accuracyVSAvoidevaluation complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent extracts and selects only the most critical fatty acid markers (C18:3n6, C18:2n6t, C20:3n3, C18:3n3, C18:2n6c, C20:4n6, C20:3n6, C22:6n3, C20:5n3) from the complex nutritional composition of breast milk. By focusing on these specific markers that have been identified as most relevant to infant communication development, the evaluation system achieves high accuracy while reducing complexity compared to analyzing all nutritional components.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent segments the complex nutritional evaluation into a simplified marker-based system. Instead of evaluating all nutritional factors comprehensively, it divides the assessment into measuring specific fatty acid markers, calculating a composite score, and interpreting communication ability development. This segmentation makes the evaluation process more manageable and cost-effective while maintaining precision.

Inventive Principle:
Principle #1Segmentation

2Measurement precision

If individualized nutritional assessment for each lactating woman is performed, then evaluation precision is improved, but time consumption and resource requirements increase

Engineering Contradiction:
Improveevaluation precisionVSAvoidtime consumption
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent develops a universal evaluation framework that can be applied to all lactating women regardless of their specific dietary patterns or racial backgrounds. The same nine fatty acid markers and scoring system serve as a multi-functional tool for assessing communication ability development across diverse populations, eliminating the need for customized evaluation protocols for each individual while maintaining high precision through the standardized marker selection.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Measurement precision

If detailed analysis of all breast milk components is conducted, then nutritional evaluation accuracy is improved, but detection cost and complexity increase

Engineering Contradiction:
Improvenutritional evaluation accuracyVSAvoiddetection complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent extracts and prioritizes the nine most significant fatty acid markers from the complex mixture of breast milk components. Research has identified these specific markers as the most relevant to infant communication development, allowing the system to achieve high nutritional evaluation accuracy by focusing measurement resources on these key components rather than analyzing all possible nutrients and compounds.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent transforms the complex multi-parameter nutritional composition data into a simplified single composite score (Ya score) based on the nine fatty acid markers. This parameter transformation reduces detection complexity by converting multiple measurement dimensions into one interpretable result, while maintaining evaluation accuracy through the weighted combination of the selected markers.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method allows for accurate inference of an infant's communication ability development, enabling timely nutritional suggestions and interventions, with a low-cost, simple, and effective approach suitable for large-scale evaluation, achieving an accuracy rate of 90.2% and sensitivity of 95%.

Implementation Method 1

measuring the contents of each marker of the marker set in the sample to be measured using gas chromatography-mass spectrometry (GC-MS)

Methodology Applied
Scientific EffectGas chromatography-mass spectrometry:

Implementation Method 2

the sample is pretreated by performing methyl esterification on the sample using a hydrochloric acid-methanol method

Methodology Applied
Scientific EffectMethyl esterification:

Data Source

PatentUS20240264179A1Marker set for evaluating the development of infant’s communication ability and use thereof
Publication Date: 2024.08.08 BEIJING SANYUAN FOOD
  • US20240264179A1 patent drawing
  • US20240264179A1 patent drawing

AI summary

The present invention provides a marker set for evaluating the development of an infant's communication ability. The marker set is composed of the following fatty acids: C18:3n6, C18:2n6t, C20:3n3, C18:3n3, C18:2n6c, C20:4n6, C20:3n6, C22:6n3, and C20:5n3. The present invention further provides a method for evaluating the development of an infant's communication ability using the marker set. The present invention achieves the evaluation on the development of an infant's communication ability by extracting and detecting the contents of particular fatty acids in a breast milk or dairy product sample fed to an infant, and the development level of the infant among the peers can be inferred based on the evaluation result, so as to give suggestions relevant to diet and nutrition for the mother timely. The method is low in cost, simple and effective, and suitable for large-scale evaluation.