Clinical Infertility Assessment Using Gene Expression Profiling
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Solution Overview
Problem
Current assisted reproductive technologies, such as in vitro fertilization (IVF), have suboptimal success rates due to implantation failure and high early pregnancy loss, leading to significant financial and psychological burdens for patients, necessitating a method to assess the likelihood of IVF success before treatment.
Innovation Solution
Development of methods and systems to assess clinical infertility by evaluating preselected patient variables, determining the probability of live birth, and optimizing embryo transfer strategies using algorithms and gene expression profiling to predict successful IVF outcomes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If IVF treatment is performed, then pregnancy may be achieved, but success rate is low with high early pregnancy loss
Solution Approach 1:
The patent applies preliminary action by measuring gene expression profiles of embryos before transfer to predict implantation success. This advance assessment allows selection of embryos with higher likelihood of successful implantation, thereby reducing early pregnancy loss and improving overall IVF success rates.
2Reliability
If multiple IVF cycles are attempted, then pregnancy probability increases, but financial and psychological burden increases
Solution Approach 1:
The patent enables preliminary assessment of embryo implantation potential through gene expression profiling before transfer. This allows patients and clinicians to make informed decisions about continuing IVF cycles, potentially avoiding unnecessary treatments and reducing cumulative financial costs while maintaining reasonable pregnancy achievement probability.
3Reliability
If embryo transfer is performed, then pregnancy may result, but implantation failure causes loss
Solution Approach 1:
The patent replaces mechanical/visual embryo assessment methods with molecular biology techniques by measuring gene expression profiles. This substitution provides more precise prediction of implantation potential, enabling selection of embryos with higher success rates and reducing implantation failure.
4Productivity
If surgical procedures are performed for egg collection and embryo implantation, then IVF treatment can be completed, but patient trauma increases
Solution Approach 1:
The patent applies preliminary action by assessing embryo quality through gene expression profiling before surgical implantation. This advance evaluation increases the likelihood of successful pregnancy establishment, potentially reducing the number of surgical procedures and associated patient trauma required to achieve pregnancy.
Data Source
AI summary
Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.