Infrared Impulse Spectroscopy for Inclusion-Independent Chemical Imaging

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Solution Overview

Problem

Existing Mid Infrared Photothermal (MIP) imaging techniques face challenges in sensitivity and data analysis, particularly when imaging resolution-scale objects, due to the dependence of the signal on inclusion size and fractal dimension, making it difficult to extract chemical composition from the measured data.

Innovation Solution

The Optically Super-resolved InfraRed Impulse Spectroscopy (OSIRIS) technique uses a low duty cycle, pulsed infrared pulse that heats the sample independently of inclusion size, allowing for direct extraction of concentration through a method that processes the signal in the time domain and employs spectral de-mixing and Bayesian analysis to infer chemical composition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If high duty cycle infrared pump is used in MIP imaging, then image acquisition speed is improved, but sensitivity deteriorates and signal depends on inclusion size rather than chemical composition

Engineering Contradiction:
Improveimage acquisition speedVSAvoidchemical composition extraction accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The patent applies periodic action by using pulsed infrared illumination instead of continuous illumination. The pulse duration is specifically controlled to be shorter than the thermal diffusion time constant, creating periodic thermal excitation that allows heat to remain localized to the inclusion rather than diffusing to surrounding areas. This periodic pulsed action enables the signal to depend on the absorptivity and concentration of the analyte rather than inclusion size, resolving the contradiction between acquisition speed and measurement precision.

Inventive Principle:
Principle #19Periodic action

2Measurement precision

If pulsed infrared illumination shorter than thermal cooling time constant is used, then sensitivity and chemical composition extraction are improved, but image acquisition rate decreases

Engineering Contradiction:
Improvechemical composition extraction accuracyVSAvoidimage acquisition rate
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The patent applies preliminary action by performing rapid sequential sampling at multiple time points immediately following the infrared pulse, capturing the thermal response before significant heat diffusion occurs. By collecting multiple time-resolved measurements during the brief thermal event and processing them through deconvolution algorithms, the method extracts chemical composition information from the temporal evolution of the signal, achieving both high measurement precision and improved acquisition rate compared to single-point sampling.

Inventive Principle:
Principle #10Preliminary action

3Measurement precision

If low duty cycle pulsed technique is used, then sensitivity and spatial resolution are improved, but signal-to-noise ratio may deteriorate due to reduced averaging

Engineering Contradiction:
Improvespatial resolution and sensitivityVSAvoidsignal-to-noise ratio
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent applies feedback through iterative deconvolution algorithms that process the time-resolved signal to extract the impulse response function. The algorithm uses the measured thermal response at multiple time points and iteratively refines the estimate of the chemical composition and thermal parameters. This computational feedback mechanism allows the system to achieve high spatial resolution and sensitivity by extracting maximum information from the limited temporal sampling, while maintaining reliable signal-to-noise ratios through mathematical reconstruction rather than simple temporal averaging.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

OSIRIS enables straightforward extraction of chemical concentrations and reduces uncertainty in imaging, providing higher sensitivity and spatial resolution by analyzing the time-domain signal, overcoming the limitations of MIP imaging.

Implementation Method 1

the change in the signal of a short wavelength scanning confocal probe is measured as the sample is heated by a modulated infrared laser

Methodology Applied
Scientific EffectInfrared absorption: Absorption (EM radiation)

Implementation Method 2

Mid Infrared Photothermal (MIP) imaging

Methodology Applied
Scientific EffectPhotothermal effect:

Data Source

PatentUS20250354924A1Optically super-resolved infrared impulse spectroscopy (osiris)
Publication Date: 2025.11.20 THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
  • US20250354924A1 patent drawing
  • US20250354924A1 patent drawing
  • US20250354924A1 patent drawing

AI summary

The present invention provides a system and method for spectroscopic imaging. In one embodiment, a system includes: a sample stage for holding a sample to be analyzed; a first light source for generating a pulse of infrared light; a second light source for generating a probing beam of infrared light; an optical system to direct the pulses of infrared light and the probing beam of infrared light at the sample, such that a temperature change is induced in an area of the sample. The duration of the pulse of infrared light is shorter than or equal to a cooling time constant of resolution scale inclusions within the sample such that the temperature change is independent of inclusion size. Light detectors are configured to detect light from the sample and digitization electronics convert data from the light detectors into signal data indicative of a chemical composition of the sample.