Infusion Pump Dosing Unit Thread Lash Elimination

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Solution Overview

Problem

Infusion pump devices face challenges with precision dosing of small volumes of liquid medicaments due to high friction and thread lash issues, leading to increased energy consumption and reduced shelf life of disposable units.

Innovation Solution

A dosing unit design with a separate bias force element to eliminate thread lash, featuring a plunger shaft with a thread and a cylinder with a threaded sleeve, where the bias force element ensures constant engagement without play, reducing friction and energy consumption while maintaining precision.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a plunger is displaced to pump small volumes of liquid medicament, then dosing function is achieved, but high friction between plunger and cylinder walls requires high actuating forces

Engineering Contradiction:
Improvedosing precisionVSAvoidactuating force
Core Design Contradiction:
Measurement precisionVSForce

Solution Approach 1:

The dosing unit is separated from the main reservoir, allowing the plunger to operate in a smaller, dedicated dosing cylinder. This segmentation enables precise dosing of small volumes (nanolitre range) while reducing the overall friction forces compared to pumping the entire reservoir volume.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

A threaded spindle acts as an intermediary mechanism between the drive system and the plunger. The threaded engagement converts rotational motion to linear displacement with mechanical advantage, reducing the actuating force required while maintaining precise control over plunger position and dosing volume.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Length of moving object

If the cross-sectional area of the plunger is reduced to limit device thickness, then compactness is improved, but friction forces increase and precision is compromised

Engineering Contradiction:
Improvedevice thicknessVSAvoiddosing precision
Core Design Contradiction:
Length of moving objectVSMeasurement precision

Solution Approach 1:

The threaded spindle mechanism replaces direct mechanical displacement methods. This substitution allows for precise plunger positioning through rotational control while maintaining a compact cross-sectional area. The thread engagement provides fine-grained control over linear displacement, achieving precision dosing without requiring large plunger dimensions.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Ease of manufacture

If thread lash is present in the threaded engagement, then assembly is simplified, but dosing precision is reduced due to play between threads

Engineering Contradiction:
Improveassembly simplicityVSAvoidthreaded engagement precision
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

A bias force element is introduced to apply preliminary compressive force to the threaded engagement. This pre-loading eliminates thread lash and play before operation begins, ensuring precise and repeatable plunger displacement. The bias force element maintains constant contact between thread flanks, preventing the play that would otherwise occur during assembly and operation.

Inventive Principle:
Principle #9Preliminary anti-action

4Reliability

If friction between plunger and cylinder is high to ensure sealing, then sealing reliability is improved, but energy consumption increases

Engineering Contradiction:
Improvesealing reliabilityVSAvoiddrive system energy consumption
Core Design Contradiction:
ReliabilityVSUse of energy by moving object

Solution Approach 1:

The system dynamically manages friction through the threaded spindle mechanism. During the dosing phase, the thread engagement provides controlled friction for precise positioning. During the return phase, the mechanism allows easier reversal by managing the friction characteristics of the thread engagement, thereby reducing overall energy consumption while maintaining sealing reliability through the plunger-cylinder interface design.

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution enhances precision, reduces energy consumption, and extends the shelf life of disposable units by minimizing thread lash and maintaining consistent frictional forces, thereby improving the overall performance and reliability of infusion pump devices.

Implementation Method 1

A separate bias force element biases the two threads in regard to each other along the longitudinal axis, such that the threaded engagement of inner thread and outer thread is free of play independent of a direction of a rotational movement and linear displacement of the plunger in regard to the cylinder

Methodology Applied
Scientific EffectRadial bias force: Force

Implementation Method 2

One of the two threads is an outer thread and the other one is an inner thread, said two threads engaging with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in an additional linear displacement of the plunger along said longitudinal axis

Methodology Applied
Scientific EffectScrew mechanism: Screw

Implementation Method 3

The plunger has a plug sealingly closing the cylinder, thereby defining a metering cavity between the cylinder head and the plug

Methodology Applied
Scientific EffectSealing: Friction

Data Source

PatentEP2750735B1Dosing unit for an ambulatory infusion device
Publication Date: 2017.09.20 F HOFFMANN LA ROCHE & CO AG
  • EP2750735B1 patent drawingFigure 1(a)~2(b)
  • EP2750735B1 patent drawingFigure 3(a)~6(b)
  • EP2750735B1 patent drawingFigure 4(a)~4(d)

AI summary

A dosing unit (1) for an infusion pump device comprises a piston pump with a pump cylinder (2) and a plunger (3) arranged within said cylinder, coaxially arranged along a longitudinal axis (20). The plunger has a shaft (32) with a thread (33, 33') and the cylinder has a threaded sleeve part (26) with a thread (23, 23'). One of the two threads is an outer thread and the other one is an inner thread, said two threads engaging with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in an additional linear displacement of the plunger along said longitudinal axis. A separate bias force element (5, 6) biases the two threads in regard to each other along the longitudinal axis, such that the threaded engagement of inner thread and outer thread is free of play independent of a direction of a rotational movement and linear displacement of the plunger in regard to the cylinder.