Inhalation Composition with Hydrogen Gas for Hypertension

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current pharmaceuticals for hypertension, such as propranolol, captopril, and amlodipine besylate, often cause negative side effects like dizziness and fatigue, limiting their long-term use due to inefficiencies in reducing blood pressure-related diseases like coronary atherosclerotic heart disease and cardiovascular disease.

Innovation Solution

An inhalation-type pharmaceutical composition combining hydrogen gas with atomized medicines like propranolol, captopril, or amlodipine besylate, where the hydrogen gas volume concentration ranges from 2 to 96%, enhancing absorption and reducing side effects through atomization and gas mixing techniques.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional pharmaceuticals (propranolol, captopril, amlodipine besylate, losartan) are used for hypertension treatment, then blood pressure control is achieved, but negative side effects (dizziness, fatigue) occur

Engineering Contradiction:

Improveblood pressure controlVSAvoidside effects (dizziness, fatigue)

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Hydrogen gas is introduced as an intermediary substance that interacts with the conventional pharmaceuticals. The hydrogen gas acts as a mediator that reduces the harmful side effects (dizziness, fatigue) while preserving the blood pressure control effect, thereby resolving the contradiction between efficacy and safety

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the physical state and delivery parameters of the pharmaceuticals from oral solid/liquid forms to atomized inhalable forms. This parameter change in delivery method, combined with hydrogen gas concentration adjustments (2-96% volume), reduces side effects while maintaining blood pressure control effectiveness

Inventive Principle:

Principle #35Parameter changes

2Duration of action of stationary object

If conventional pharmaceuticals are used for long-term hypertension treatment, then blood pressure is controlled, but patient compliance decreases due to side effects

Engineering Contradiction:

Improvelong-term treatment durationVSAvoidpatient compliance

Core Design Contradiction:

Duration of action of stationary objectVSEase of operation

Solution Approach 1:

Hydrogen gas serves as a protective intermediary that mitigates the harmful effects of conventional pharmaceuticals during long-term use. This reduces patient discomfort and improves compliance, enabling sustained long-term treatment without the burden of severe side effects

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

Changing the delivery parameter from oral to inhalational form improves patient ease of use and compliance. The atomized delivery system with hydrogen gas enhancement provides a more tolerable long-term treatment experience, improving patient adherence

Inventive Principle:

Principle #35Parameter changes

3Productivity

If multiple pharmaceuticals are combined for advanced therapy, then treatment efficiency improves, but complexity and side effect accumulation increase

Engineering Contradiction:

Improvetreatment efficiencyVSAvoidtherapy complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The invention merges multiple pharmaceutical functions into a single inhalation composition containing hydrogen gas and atomized medicines. This consolidation maintains treatment efficiency while reducing the complexity of managing multiple separate medications and their cumulative side effects

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides effective hypertension treatment by improving medication absorption and reducing harmful radicals in the body, offering better curative effects with reduced side effects and increased convenience.

Implementation Method 1

improving medication absorption and reducing harmful radicals in the body

Methodology Applied

Scientific EffectFree radical reduction: Oxidation

Implementation Method 2

atomized medicine is selected from a group comprising propranolol, captopril, amlodipine besylate, losartan

Methodology Applied

Scientific EffectAtomization: Aerosol

Implementation Method 3

the first gas is a gas mixture of hydrogen and oxygen generated from electrolyzing water, where the volume ratio of hydrogen to oxygen is 2:1

Methodology Applied

Scientific EffectElectrolysis: Electrolysis

Data Source

PatentUS9827193B2Inhalation-type pharmaceutical composition for the treatment of hypertension and preparation method thereof

Publication Date: 2017.11.28 LIN HSIN YUNG

AI summary

The present invention provides an inhalation-type pharmaceutical composition for hypertension and preparation method thereof, comprising a first gas and an atomized medicine. The first gas comprises hydrogen. The gas volume concentration of hydrogen in the inhalation-type pharmaceutical composition is between 2 to 96%. The atomized medicine is selected from a group comprising propranolol, captopril, amlodipine besylate, losartan, and any combination thereof. The inhalation-type pharmaceutical composition of the present invention can remove harmful radicals in the body of the patient through the use of hydrogen while also increases the absorption effect of the medicine for the patient by using an atomized medicine. At the same time, because the use of the small amount of the vaporized pharmaceutical liquid can indirectly reduce the side effects on the user.