Injectable Bone Cement with Demineralized Bone Matrix Fibers
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Solution Overview
Problem
Current injectable cements for filling bone voids provide insufficient structural support and do not adequately optimize natural bone growth, despite being load-bearing.
Innovation Solution
A composition combining demineralized bone matrix fibers with an injectable settable cement, where the demineralized bone matrix fibers comprise 20-60% by volume, offering initial fracture stability and promoting de novo bone growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If known injectable cements are used to fill bone voids, then load-bearing capability is provided, but natural bone growth is not sufficiently optimized
Solution Approach 1:
The patent combines demineralized bone matrix (DBM) fibers with injectable cement to create a composite material that simultaneously provides mechanical strength and osteoinductive properties. The DBM fibers contain growth factors that stimulate bone formation, while the cement matrix provides structural support and load-bearing capability, resolving the contradiction between strength and bone growth optimization.
Solution Approach 2:
The patent modifies the composition parameters of the cement by incorporating specific concentrations of DBM fibers (at least 10% by volume) and growth factors into the cement matrix. This parameter change transforms the cement from a purely structural material to one that also actively promotes bone regeneration, addressing the insufficiency of known cements in optimizing natural bone growth.
2Reliability
If demineralized bone matrix fibers are added to injectable cement, then bone growth is optimized, but structural support may be compromised
Solution Approach 1:
The composite structure distributes mechanical loads through the cement matrix while the DBM fibers provide biological functionality. The cement acts as a load-bearing scaffold that maintains structural integrity, while the embedded DBM fibers concentrate at bone-defect interfaces to provide osteoinductive effects, thus maintaining both structural support and bone growth optimization.
Solution Approach 2:
The DBM fibers are distributed within the cement matrix to provide localized osteoinductive effects at the bone-defect interface, while the cement matrix provides uniform structural support throughout the graft material. This local quality differentiation allows the material to simultaneously excel in both structural support and bone growth promotion where needed.
3Reliability
If high concentration of demineralized bone matrix fibers is used, then osteoinductive capability is enhanced, but injectability and manipulation become difficult
Solution Approach 1:
The patent optimizes the concentration parameter of DBM fibers within a specific range (at least 10% by volume, preferably 20-60%) to balance osteoinductive capability with injectability. This parameter optimization ensures sufficient growth factor content for bone regeneration while maintaining the flow properties necessary for injection through surgical catheters and proper manipulation during surgery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves superior initial fracture stability and bone grafting efficacy, fostering natural bone growth and resorption, thereby enhancing bone regeneration.
Implementation Method 1
highly osteoinductive demineralized bone matrix fibers
Implementation Method 2
injectable settable cement
Data Source
AI summary
Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.