Injectable Collagen Gelation for Removable Sustained Drug Delivery
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Solution Overview
Problem
Existing collagen-based drug delivery systems for sustained release are not fully satisfactory, as they often lack removability after drug release, increase implantation difficulty, and may compromise biocompatibility due to crosslinking for degradation resistance.
Innovation Solution
Developed injectable and sprayable, in situ polymerizable collagen compositions that remain stable at neutral pH, allowing homogeneous mixing with active agents and rapid polymerization upon contact with physiological fluids, forming fibrous matrices for controlled and sustained delivery of drugs, proteins, or therapeutic agents, with adjustable resorption rates and biocompatibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If collagen compositions are used for sustained delivery of active agents, then delivery duration is improved, but removability after drug release deteriorates
Solution Approach 1:
The collagen composition is designed to dynamically change its physical state from soluble injection form to gel matrix form upon contact with physiological fluids. This dynamic transformation enables the system to provide sustained delivery while maintaining removability, as the gel can be resorbed or removed after fulfilling its delivery function.
Solution Approach 2:
The patent utilizes changes in physical and chemical parameters (temperature, pH, concentration) to control the gelation and polymerization of collagen. By adjusting these parameters, the composition achieves sustained delivery capability while maintaining the ability to be removed or resorbed after the delivery period.
2Manufacturing precision
If collagen compositions are used for sustained delivery, then delivery control is improved, but implantation difficulty worsens
Solution Approach 1:
The collagen composition is provided as a soluble, injectable solution that can be administered through simple injection or spray methods, avoiding complex surgical implantation. The system segments the delivery process into two stages: easy administration of soluble composition, followed by in situ gelation and controlled release.
Solution Approach 2:
The patent replaces complex mechanical implantation systems with a chemical solution-based approach. The collagen composition is administered as a liquid solution that undergoes gelation in situ, eliminating the need for complex surgical insertion while maintaining precise control over delivery parameters through chemical formulation.
3Stability of the object's composition
If crosslinking is used to improve degradation resistance, then structural stability is improved, but biocompatibility deteriorates
Solution Approach 1:
The collagen composition is designed as a biodegradable, temporary structure that performs its delivery function and then naturally resorbs. This approach eliminates the need for permanent crosslinked structures, maintaining biocompatibility while providing sufficient structural stability during the delivery period through controlled degradation.
Solution Approach 2:
The patent uses controlled changes in collagen structure through parameters like temperature and pH to achieve the desired balance between stability and biocompatibility. The composition maintains structural integrity long enough for drug delivery while allowing natural degradation and resorption, avoiding the need for crosslinking that would compromise biocompatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The collagen compositions provide biocompatible, biodegradable, and stable delivery systems that allow precise control over drug release duration, minimize invasive injury, and reduce side effects by local delivery, while supporting tissue growth and minimizing unnecessary exposure to surrounding tissues.
Implementation Method 1
upon contact with the tissue, the solution is converted to a gel
Implementation Method 2
rapidly undergo gelation and polymerization to form fibrous gel matrices
Data Source
AI summary
Provided herein is injectable and/or sprayable, in situ polymerizable collagen-based compositions for sustained delivery of therapeutics (active agents, such as drugs, proteins, and other therapeutic agents). The compositions comprise (i) a neutral collagen solution, which is injectable or sprayable and capable of converting into a fibrous collagen mass or gel upon contacting with a physiological fluid or solution, or water; and (ii) a biologically or pharmaceutically active agent in the neutral collagen solution. The compositions are in the form of clear, transparent viscous solutions that instantaneously undergo gelation and polymerization when contacted by physiological fluids or solutions or water. The collagen solutions can be manipulated to provide various rates of sustained delivery of therapeutics.