Injectable Amphiphilic Copolymer Composition for Deep Tissue Repair
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Solution Overview
Problem
Existing injectable agents for tissue repair, such as hyaluronic acid gels and synthetic polymers like polycaprolactone or polylactic acid, face issues with high viscosity, particle size, side effects, and biodegradability, making them unsuitable for deep skin injections and prone to complications like filler clumping and granulomas.
Innovation Solution
A composition comprising a copolymer of hydrophilic and hydrophobic biocompatible polymers with a weight ratio of 1:1 to 15:1 and molecular weight of 1,000 to 10,000 g/mol, which has a viscosity that decreases with temperature, allowing for easy injection and biodegradation within 12 weeks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hyaluronic acid gels are used as injectable agents for tissue repair, then biocompatibility and reabsorption are improved, but particle size and viscosity increase causing difficulty in injection into narrow and deep skin scars
Solution Approach 1:
The patent changes the molecular weight parameter of hyaluronic acid to 1,000-10,000 g/mol (lower than conventional products), which directly reduces particle size and viscosity while maintaining biocompatibility and collagen regeneration effects, enabling easy injection into narrow and deep skin scars
Solution Approach 2:
The patent creates a composite material by combining hyaluronic acid with other biocompatible polymers in specific ratios, forming a copolymer that maintains the benefits of hyaluronic acid (biocompatibility, collagen regeneration) while reducing the drawbacks (high viscosity, large particle size) through synergistic interactions between components
2Reliability
If existing synthetic polymers like polycaprolactone or polylactic acid are used for tissue repair, then tissue repair effect is improved, but side effects such as clumping and non-inflammatory nodules occur requiring surgical removal
Solution Approach 1:
The patent optimizes the molecular weight of polycaprolactone to 1,000-10,000 g/mol and controls the copolymer composition ratio, which reduces particle size to prevent clumping and nodule formation while maintaining continuous tissue repair effect through controlled biodegradation within 12 weeks
Solution Approach 2:
The patent creates an amphiphilic copolymer combining hydrophilic and hydrophobic segments, where the hydrophilic portions improve biocompatibility and reduce inflammatory responses, while the hydrophobic portions maintain tissue repair efficacy, achieving synergistic effects that eliminate side effects
3Duration of action of moving object
If polycaprolactone or polylactic acid is applied subcutaneously for continuous tissue repair effect, then biodegradability of 12 to 24 months is achieved, but granulomas occur when applied intradermally
Solution Approach 1:
The patent reduces the molecular weight of polycaprolactone to 1,000-10,000 g/mol and controls the copolymer structure, which accelerates biodegradation to within 12 weeks while reducing particle size to prevent granuloma formation, making the material safe for both subcutaneous and intradermal applications
Solution Approach 2:
The patent creates an amphiphilic copolymer with different local properties: hydrophilic segments that interact favorably with aqueous environments and reduce inflammatory responses in intradermal applications, and hydrophobic segments that maintain structural integrity and tissue repair function, allowing the same material to be safely used in different injection sites
4Reliability
If particles of existing injectable agents are prepared with relatively high viscosity and elasticity for physical tissue repair, then tissue repair capability is improved, but high injection force is required causing patient pain and procedure inconvenience
Solution Approach 1:
The patent reduces viscosity by lowering molecular weight to 1,000-10,000 g/mol and optimizing copolymer composition, which decreases injection force requirements while maintaining tissue repair capability through controlled biodegradation and collagen regeneration effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides excellent biocompatibility, collagen regeneration, and thermosensitivity, reducing injection force and minimizing side effects, with small particle sizes and controlled biodegradation.
Implementation Method 1
having thermosensitivity, being injectable into the body
Implementation Method 2
the composition has a viscosity that decreases with temperature
Implementation Method 3
controlled biodegradation
Implementation Method 4
biodegradability, making them unsuitable for deep skin injections
Data Source
AI summary
The present invention relates to a composition for tissue repair, the composition comprising a copolymer of a hydrophilic biocompatible polymer and a hydrophobic biocompatible polymer. The composition can be used as a composition for tissue repair due to being rapidly biodegradable in the body and having excellent biocompatibility and collagen regeneration effects, and can also be used as an injectable agent due to having the excellent property of being injectable into the body.