Injectable Hard Tissue Regeneration Composition With Shape Retention
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Solution Overview
Problem
Existing graft materials for hard tissue regeneration face challenges in maintaining shape and adhesion, are difficult to inject into irregular defects, and may cause surgical tool adherence, leading to decreased workability and ineffective tissue regeneration.
Innovation Solution
A composition comprising crosslinked hyaluronic acid particles with an average diameter of 3 μm to 250 μm and transforming growth factor-beta (TGF-β) is developed, offering high adhesive force and viscosity, allowing easy injection and shape maintenance during tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If the compressive strength and yield value of graft material are increased to maintain location and shape, then the mechanical properties are improved, but the adhesiveness increases causing the material to stick to surgical tools during surgery
Solution Approach 1:
The patent applies parameter changes by controlling the particle size of crosslinked hyaluronic acid within a specific range (3 μm to 250 μm) and adjusting the concentration of transforming growth factor-beta (TGF-β) to achieve optimal balance between compressive strength and adhesiveness. This allows the graft material to maintain adequate mechanical properties while reducing excessive adhesion to surgical tools during injection and filling procedures.
2Strength
If the adhesiveness of graft material is increased to improve bonding to surrounding tissue, then the tissue adhesion is improved, but the material sticks to surgical tools making it difficult to fill bone defects
Solution Approach 1:
The patent optimizes the particle size parameters of crosslinked hyaluronic acid (3 μm to 250 μm) and adjusts TGF-β concentration to achieve a balance where the material has sufficient adhesiveness to bond to surrounding tissue while maintaining adequate workability during surgical procedures, preventing excessive sticking to surgical tools.
3Shape
If the viscosity of graft material is increased to maintain shape during regeneration, then the shape stability is improved, but the extrusion force increases making injection difficult
Solution Approach 1:
The patent applies parameter changes by controlling the particle size distribution of crosslinked hyaluronic acid within the range of 3 μm to 250 μm and adjusting TGF-β concentration to achieve optimal viscosity. This enables the graft material to maintain its shape during the regeneration period while keeping the extrusion force at a manageable level for easy injection into defect areas.
Data Source
AI summary
Provided is a composition for hard tissue regeneration.