Injectable Ice Slurry Composition for Precise Tissue Cryolysis
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Solution Overview
Problem
Existing technologies lack the necessary resolution and specificity in targeting selected tissues while minimizing harm to non-selected tissues.
Innovation Solution
A slurry comprising sterile ice particles with a largest cross-sectional dimension less than 1.5 mm and a biocompatible surfactant, which can include therapeutic compounds, is injected into treatment regions to selectively or non-selectively disrupt tissue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional methods are used to deliver therapeutic agents, then treatment coverage is achieved, but resolution and specificity are insufficient causing harm to non-targeted tissues
Solution Approach 1:
The ice slurry is divided into small particles (average diameter 0.5-2 mm) that can be precisely distributed through injection needles into specific tissue regions, enabling targeted delivery while avoiding damage to surrounding non-targeted tissues
Solution Approach 2:
The slurry composition is specifically designed with ice particles, surfactants, and optional therapeutic compounds to provide localized cooling and therapeutic effects only at the injection site, achieving high specificity for the targeted tissue while leaving other tissues unaffected
2Manufacturing precision
If ice particles are made smaller for better tissue penetration, then targeting resolution improves, but slurry viscosity and injection difficulty increase
Solution Approach 1:
A biocompatible surfactant is added to the ice slurry to reduce surface tension and prevent ice particle aggregation, maintaining low viscosity and smooth flow characteristics that facilitate easy injection through needles while preserving the small particle size needed for high-resolution tissue targeting
Solution Approach 2:
The slurry is maintained at controlled sub-zero temperatures to prevent ice particle growth and melting, ensuring particles remain small enough for precise targeting while maintaining slurry流动性 for easy injection through appropriate gauge needles
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The slurry achieves precise tissue disruption and cooling, minimizing damage to non-targeted tissues through controlled ice particle size and biocompatible additives, enabling targeted cryotherapy and cryolysis.
Implementation Method 1
The slurry effectively cools tissues to disrupt targeted areas, achieving selective tissue disruption and minimizing harm to non-targeted tissues through precise temperature control and composition
Implementation Method 2
a biocompatible surfactant
Data Source
AI summary
A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.