Injectable Native Component Mixture for Tissue Repair
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Solution Overview
Problem
Current methods for tissue repair and replacement are costly and inefficient, with transplanted stem cells showing short-term survival and limited long-term success due to poor integration and scarring, and existing bio-engineered tissues often result in scar tissue formation rather than functional integration with surrounding tissue.
Innovation Solution
A medical composition comprising a mixture of native components, such as growth factors and extracellular matrix proteins, produced by culturing cell samples from human or animal tissues, combined with a pharmaceutically acceptable carrier, which is injectable and designed to enhance tissue repair by recruiting and differentiating progenitor cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If transplanted stem cells are used for tissue repair, then cell replacement is achieved, but long term survival and integration are poor resulting in scarring
Solution Approach 1:
The patent applies preliminary action by pre-culturing cells ex vivo to produce growth factors and extracellular matrix proteins before transplantation. This preparatory step creates a bioactive environment that enhances subsequent cell survival and integration, avoiding the scarring problem associated with direct transplantation of non-prepared cells.
Solution Approach 2:
The patent uses growth factors and extracellular matrix proteins as intermediary substances that mediate between the transplanted cells and the host tissue environment. These intermediaries facilitate proper integration and reduce scarring by creating a favorable microenvironment for cell survival and tissue regeneration.
2Reliability
If bio-engineered tissue is used for replacement, then tissue repair is achieved, but integration with surrounding tissue is poor leading to scar tissue formation
Solution Approach 1:
The patent applies parameter changes by modifying the biochemical properties of the tissue construct through ex vivo culturing. The tissue is treated to develop specific growth factor profiles and extracellular matrix characteristics that promote integration with surrounding tissue, thereby preventing scar formation while maintaining reliable tissue replacement.
3Reliability
If cell culturing is performed to produce growth factors, then tissue repair capability is enhanced, but production time and cost increase
Solution Approach 1:
The patent applies partial action by culturing cells for a specific optimized duration to achieve sufficient growth factor production without unnecessary extension. This approach produces adequate quantities of repair-promoting substances while minimizing time and resource expenditure, balancing effectiveness with efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition promotes effective tissue repair by enhancing cell proliferation and differentiation, reducing scarring, and improving integration with existing tissue, as demonstrated by preliminary studies showing vascular ingrowth and new bone formation.
Implementation Method 1
adding one or several different cell samples of human or animal origin to a bioreactor containing a nutrient medium, wherein a culturing medium is obtained; cell culturing during normal conditions; drawing off at least once the culturing medium including the native components produced during the cell culturing
Implementation Method 2
separating the native components from the culturing medium thereby obtaining a mixture of native components
Implementation Method 3
separating the native components from the culturing medium thereby obtaining a mixture of native components
Data Source
AI summary
A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection. A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection.