Injectable Nutritional Supplement Stabilization
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing injectable formulations of vitamin B12 and trace elements for livestock are unstable in aqueous solutions, leading to degradation during storage and administration, which affects their efficacy in correcting vitamin B12 deficiencies.
Innovation Solution
An aqueous injectable nutritional supplement composition comprising an EDTA complex of one or more trace elements, vitamin B12, and a water-soluble liquid such as propylene glycol, which stabilizes vitamin B12 against degradation even in the presence of high concentrations of trace element complexes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If vitamin B12 and trace elements are combined in an aqueous injectable formulation, then convenience of administration and tissue compatibility are improved, but stability during storage deteriorates due to degradation of vitamin B12
Solution Approach 1:
The patent introduces glycols (such as propylene glycol, ethylene glycol, or polyethylene glycol) as intermediary substances that stabilize vitamin B12 in the aqueous injectable formulation. These glycols act as mediators between the aqueous environment and vitamin B12, preventing degradation while maintaining solubility and tissue compatibility. The glycols form a protective environment that allows vitamin B12 to remain stable during storage without requiring separate administration of vitamin B12 and trace elements.
2Quantity of substance
If trace element concentration is increased to acceptable levels in a single injection, then nutritional efficacy is improved, but stability of vitamin B12 deteriorates due to exacerbated degradation
Solution Approach 1:
The glycols introduced in the patent serve as intermediaries that protect vitamin B12 from degradation even in the presence of high concentrations of trace elements. The glycols create a stabilizing environment that allows the formulation to contain therapeutic levels of trace elements (such as copper, zinc, manganese, selenium, and chromium) without compromising vitamin B12 stability. This intermediary effect enables the co-administration of high concentrations of trace elements and vitamin B12 in a single stable formulation.
3Stability of the object's composition
If previously reported strategies for controlling degradation are applied, then some stability improvement is achieved, but effectiveness is insufficient for aqueous compositions containing trace element complexes
Solution Approach 1:
The patent applies parameter changes by selecting specific glycols (propylene glycol, ethylene glycol, or polyethylene glycol) with particular molecular weights and concentrations optimized for stabilizing vitamin B12 in the presence of trace element complexes. This goes beyond previously reported strategies by identifying specific glycol types and their optimal concentrations that effectively prevent degradation. The parameter optimization ensures reliable stability and effectiveness of the formulation during storage and administration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides a stable and effective injectable form of vitamin B12 and trace elements, maintaining their potency during storage and administration, thereby addressing vitamin B12 deficiencies in livestock.
Implementation Method 1
a water-soluble liquid selected from the group consisting of propylene glycol, glycol ethers of molecular weight no more than 300, polyethylene glycol of molecular weight no more than 300, dipropylene glycol monomethyl ether and mixtures thereof
Data Source
AI summary
An aqueous injectable nutritional supplement composition for livestock, comprising: an EDTA complex of one or more trace elements; vitamin B12; and a water-soluble liquid selected from glycols, glycol ethers and mixtures thereof.