Injectable Polymeric Particles for Stable Tissue Augmentation

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Solution Overview

Problem

Current treatments for urinary incontinence and vesico-ureteral reflux provide only temporary relief due to issues with biodegradable materials and particle migration, leading to a need for a long-lasting, safe, and effective tissue bulking solution.

Innovation Solution

An injectable composition of highly anionic, polymeric particles with an irregular shape and a biocompatible carrier, which are non-biodegradable and have a lubricated surface, allowing for stable tissue bulking through the use of crosslinked sodium polyacrylate polymers and a pegylated form, ensuring minimal interaction with peripheral cells and avoiding side effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If biodegradable polymers (collagen, hyaluronic acid) are used for tissue augmentation, then biocompatibility is improved, but the duration of action deteriorates due to degradation and spreading

Engineering Contradiction:

ImprovebiocompatibilityVSAvoidduration of tissue augmentation

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent changes the biodegradability parameter from biodegradable to non-biodegradable, using crosslinked synthetic polymers (polyacrylonitrile, polyacrylamide, carboxymethyl cellulose) that resist enzymatic degradation. This parameter change maintains biocompatibility while dramatically extending the duration of tissue augmentation effect from months to years

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses composite material structures combining synthetic non-biodegradable polymer networks with crosslinking agents to create stable gel matrices. These composite gels provide long-term structural support while maintaining biocompatibility, resolving the contradiction between durability and biocompatibility

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If small PTFE particles are used in formulations, then ease of injection is improved, but harmful factors worsen due to particle migration and granulomatous reactions

Engineering Contradiction:

Improveease of injectionVSAvoidparticle migration and granulomatous reaction

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent changes the particle size parameter to larger dimensions (10-1000 μm, preferably 50-500 μm) and modifies the polymer chemistry from PTFE to crosslinked acrylic polymers. This parameter change prevents particle migration and granulomatous reactions while maintaining injectability through the use of deformable gel structures that can pass through catheters during injection

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the potential harm of particle migration into a benefit by using larger, non-migrating particles that provide stable, localized tissue augmentation. The crosslinked gel structure ensures particles remain固定在 the injection site, transforming the migration problem into a stable positioning solution

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Object-affected harmful factors

If large polymer particles are used to prevent migration, then harmful factors are reduced, but ease of operation deteriorates due to difficulty in injection

Engineering Contradiction:

Improveparticle migrationVSAvoidease of injection

Core Design Contradiction:

Object-affected harmful factorsVSEase of operation

Solution Approach 1:

The patent introduces dynamic properties to the polymer particles, making them deformable and flexible within a gel matrix. This allows large particles (10-1000 μm) to dynamically change shape and size during injection, passing through catheters easily, then return to their stable large size at the injection site to prevent migration

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The patent utilizes phase transition properties of the gel matrix, which transitions from a flowable state during injection to a stable gel state at the injection site. This phase transition enables large particles to be injected easily in the flowable state while maintaining their large size and preventing migration in the gel state

Inventive Principle:

Principle #36Phase transitions

Data Source

PatentUS9017709B2Composition comprising polymeric, water-insoluble, anionic particles, processes and uses

Publication Date: 2015.04.28 PROMEDON DO BRASIL PROD MEDICO HOSPITALARES

AI summary

The present invention relates to an injectable composition which comprises polymeric, water-insoluble, non-biodegradable, anionic particles, these particles having an irregular shape and a biocompatible carrier with a lubricated surface, a method for preparing the same, a method for treating a tissue in a patient which comprises injecting into the tissue site the injectable composition as a permanent implant and the use of the injectable composition as a medicament, particularly for bulking a tissue site.