Prefilled Injection Device Plunger Protrusion Compression

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Solution Overview

Problem

Existing pre-filled injection devices for intramuscular injections are often complex and expensive, and many are not capable of delivering medication at a slow, steady rate, which is necessary for comfort and effective absorption by tissues.

Innovation Solution

A low-cost, uncomplicated prefilled injection device with a pre-filled drug container, a body, and a plunger that moves telescopically with protrusions to compress the container perpendicular to its movement, allowing for a single-plane compression and slow, steady drug delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pre-filled injection devices are made complex to achieve slow steady delivery, then medication delivery control is improved, but device complexity and manufacturing cost increase

Engineering Contradiction:
Improvemedication delivery controlVSAvoiddevice complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent changes the physical state and geometry of the drug container by compressing it into a single plane, transforming it from a three-dimensional structure to a two-dimensional structure. This parameter change enables the container to be compressed effectively by the plunger's protrusions, allowing for controlled medication delivery without complex mechanisms.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The plunger is segmented with at least one pair of protrusions that work in concert to compress the drug container. This segmentation allows the plunger to apply distributed force to the container, enabling precise control over the compression and medication delivery rate, achieving slow steady delivery (not exceeding 1 mL per 10 seconds) through a simple mechanical design.

Inventive Principle:
Principle #1Segmentation

2Ease of manufacture

If pre-filled injection devices are simplified to reduce cost, then manufacturing cost is reduced, but capability to deliver medication at slow steady rate is lost

Engineering Contradiction:
Improvemanufacturing costVSAvoidmedication delivery rate control
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The drug container is pre-compressed into a single plane before the injection process. This preliminary action prepares the container for controlled compression during injection, enabling the simple plunger design to achieve reliable slow steady medication delivery without requiring complex mechanisms or increasing manufacturing cost.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent reduces the drug container from a three-dimensional structure to a two-dimensional single-plane structure. This dimensional change allows the container to be effectively compressed by the plunger's protrusions, enabling controlled medication delivery through a simple, low-cost mechanical design without compromising delivery rate control capability.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Adaptability or versatility

If medication is transferred from separate vial to injection device, then flexibility is improved, but time consumption and risk of contamination increase

Engineering Contradiction:
ImproveflexibilityVSAvoidtime consumption
Core Design Contradiction:
Adaptability or versatilityVSLoss of time

Solution Approach 1:

The patent merges the drug storage function and injection function into a single integrated pre-filled device. The drug container is permanently sealed within the device body, eliminating the need for separate vials and needle transfer operations. This merging reduces time consumption and eliminates contamination risks associated with transferring medication from separate vials to the injection device.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device provides a cost-effective, user-friendly method for intramuscular injections that ensures a slow and steady medication delivery, promoting comfort and efficient absorption, while avoiding the need for needle changes and separate vial transfers.

Implementation Method 1

the protrusions work in concert to compress the drug container by applying a force to the drug container that is perpendicular to the movement of the plunger

Methodology Applied
Scientific EffectMechanical Force: Mechanical Force

Data Source

PatentUS10500338B2Prefilled disposable injection device
Publication Date: 2019.12.10 MERCK SHARP & DOHME LLC
  • US10500338B2 patent drawing
  • US10500338B2 patent drawing
  • US10500338B2 patent drawing

AI summary

A drug delivery device comprising a drug container extending between a distal end and a proximal end and is capable of being compressed into a single plane; a body extending between proximal and distal ends comprising a hollow space for containing the drug container; and a plunger extending between proximal and distal ends, wherein the distal end of the plunger engages telescopically with the proximal end of the body, wherein the plunger comprises at least one pair of protrusions, wherein the protrusion is capable of compressing the drug container as the plunger moves towards the proximal end of the drug delivery device, by applying a force to the drug container that is perpendicular to the movement of the plunger.