Injection-Port Dropper Bottle for Point-of-Service Reconstitution
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Solution Overview
Problem
The existing compounding pharmacies are limited in capacity and availability, leading to a critical delay in providing compounded medications for treating infectious keratitis, which can result in severe infection and permanent eye damage due to antimicrobial shortages and lack of immediate access to un-reconstituted dry or anhydrous formulations.
Innovation Solution
A dropper bottle assembly with an integrated injection port and lateral conveyance tube allows for the storage and rapid reconstitution of pharmaceutical and nutraceutical compounds in pre-filled sterile containers, enabling immediate administration of eye drops at the point of service.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If compounding pharmacies are used to provide customized medications, then medication availability is improved, but access time and capacity are limited due to geographic and operational constraints
Solution Approach 1:
The patent applies preliminary action by providing un-reconstituted dry or anhydrous formulations of pharmaceutical compounds in pre-filled sterile containers to clinicians before the actual treatment is needed. This allows the medication to be prepared and stored in advance, eliminating the need for time-consuming compounding processes at the point of service and enabling immediate administration when required.
Solution Approach 2:
The patent extracts the compounding process from the point of service by providing pre-prepared, un-reconstituted formulations that can be directly administered. This removes the time-consuming steps of mixing, dissolving, and preparing customized medications at the clinic, allowing clinicians to immediately administer the medication when needed.
2Adaptability or versatility
If compounding pharmacies prepare customized medications, then medication specificity is improved, but production capacity and availability are limited
Solution Approach 1:
The patent applies preliminary action by having compounding pharmacies prepare and package un-reconstituted dry or anhydrous formulations in advance. This allows the complex compounding process to be completed beforehand, while the final reconstitution and administration occur immediately at the point of service, thereby maintaining medication specificity while improving overall productivity.
Solution Approach 2:
The patent segments the medication preparation process into two distinct phases: (1) the compounding phase where customized formulations are prepared and packaged in pre-filled sterile containers, and (2) the reconstitution phase where the dry formulation is rapidly reconstituted at the point of service. This segmentation allows each phase to be optimized independently, maintaining medication specificity while improving production capacity.
3Reliability
If immediate treatment is initiated for infectious keratitis, then patient outcome is improved, but access to un-reconstituted formulations is limited
Solution Approach 1:
The patent extracts the need for complex reconstitution procedures by providing un-reconstituted dry or anhydrous formulations that can be directly administered. This removes the barrier of requiring specialized equipment and time for reconstitution, enabling immediate treatment initiation while maintaining ease of operation at the point of service.
Solution Approach 2:
The patent employs disposable pre-filled sterile containers containing un-reconstituted dry or anhydrous formulations. These single-use containers eliminate the need for reusable reconstitution equipment and simplify the administration process, allowing immediate treatment while maintaining ease of operation through a simple, disposable system.
Data Source
AI summary
Disclosed herein are embodiments of dropper bottle assemblies which feature bottles with an injection port, allowing a medical provider, nutritionist, or other person to introduce into the bottle a diluent to reconstitute anhydrous or dry active pharmaceutical or nutraceutical compounds stored in the bottle at point of service, and to administer to a patient or other subject drops of the resulting solution. Methods of use are also disclosed, in which such dropper bottle assemblies may be employed to reconstitute compounds using a sterile needle and sterile syringe, and thereafter administer a solution to a patient or other subject.