Fluid Injector Partial Dose Delivery via Dilution
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Solution Overview
Problem
In medical procedures, especially those involving small volumes of therapeutic agents or contrast agents, the dead volume in fluid delivery paths poses challenges in accurately delivering the desired dose due to the need for dilution and accounting for non-deliverable volumes, which complicates the calculation of the maximum deliverable dose and partial dose delivery.
Innovation Solution
A method and system that involve diluting a first substance with a second substance in a fluid reservoir, calculating the total volume, and determining the concentration and maximum deliverable dose, allowing for precise calculation and delivery of a desired dose by accounting for the dead volume in the fluid path, using a fluid delivery system with a controller to manage the injection process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If the fluid volume is increased by dilution to compensate for dead volume, then the deliverable dose is improved, but the complexity of calculating the maximum deliverable dose increases
Solution Approach 1:
The system uses feedback mechanisms where the controller monitors the actual volume delivered and compares it with the target dose. Based on this feedback, the system automatically adjusts the calculated volume to account for dead volume, ensuring accurate dose delivery without requiring complex manual calculations.
Solution Approach 2:
The system performs self-calibration by automatically measuring and accounting for dead volume in the fluid path. The controller independently calculates the maximum deliverable dose based on the diluted concentration and dead volume parameters, eliminating the need for external intervention or complex user calculations.
2Measurement precision
If the full volume of fluid is injected to account for dead volume, then the dose accuracy is improved, but the loss of substance increases due to waste
Solution Approach 1:
Instead of injecting the full volume, the system calculates and delivers only the necessary partial volume required to achieve the target dose after accounting for dead volume. This partial action approach ensures that exactly the required amount of substance is delivered, minimizing waste while maintaining dose accuracy.
Solution Approach 2:
The system changes the concentration parameter by diluting the fluid to a known concentration, then uses this modified parameter to calculate the precise volume needed. This parameter change allows for accurate dose delivery without requiring excessive fluid volumes, thereby reducing substance loss.
3Productivity
If the concentration is increased to reduce the volume needed, then the productivity is improved, but the manufacturing precision requirements increase
Solution Approach 1:
The system performs preliminary dilution of the fluid to a known concentration before delivery. This preliminary action simplifies the subsequent delivery process by establishing a controlled concentration base, allowing for easier volume calculations and reducing the precision requirements during the actual delivery phase.
Solution Approach 2:
The diluted fluid acts as an intermediary medium between the concentrated substance and the final delivery. This intermediary approach allows the system to work with more manageable volumes and concentrations, improving productivity while the controlled dilution process maintains necessary precision through standardized preparation procedures.
Data Source
AI summary
Methods and systems for diluting a dose of a substance to be delivered to a patient and for determining a maximum deliverable dose of the substance and/or a partial fluid volume to be delivered to the patient to provide a desired dose amount are provided. The method includes the step of providing a first substance within a fluid reservoir having an initial unit value. The method also includes diluting the first substance with a second substance to produce the diluted solution. Once the first substance is diluted, a total volume (VTotal) of the diluted solution is measured. A concentration of the diluted solution is then calculated based on the initial unit value and the total volume (VTotal). A fluid delivery system including a fluid reservoir and fluid delivery device, which is configured to perform the method, is also provided.