Inkjet Printing Bioactive Agents on Hemostatic Matrix
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Solution Overview
Problem
Existing hemostatic devices fail to achieve a uniform distribution of bioactive agents like thrombin on a matrix material, leading to inefficiencies in hemostasis and wound healing, as conventional methods such as spraying result in waste and non-uniform application.
Innovation Solution
A method involving inkjet printing technology to precisely deposit bioactive agents, such as thrombin, onto the surface of a matrix material in discrete and individual locations, ensuring a uniform distribution and preventing matrix swelling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional spraying methods are used to apply bioactive agents onto matrix material, then the application process is simple and fast, but the distribution of bioactive agents is non-uniform and material waste occurs
Solution Approach 1:
The patent segments the application process into discrete droplet deposits at specific locations on the matrix material, rather than continuous spraying. This segmentation allows precise control over where and how much bioactive agent is applied, achieving uniform distribution while reducing waste through targeted placement only where needed.
Solution Approach 2:
The patent applies different amounts of bioactive agents at different locations on the matrix material based on specific requirements. By using inkjet printing technology, the system can vary the droplet size, frequency, and placement location to achieve optimal local concentration, ensuring uniform overall distribution while allowing for localized adjustments.
2Manufacturing precision
If large amounts of bioactive agents are applied to ensure coverage, then uniform distribution is achieved, but material waste increases and cost rises
Solution Approach 1:
The patent applies bioactive agents partially and precisely only where needed on the matrix material, rather than excessive application across the entire surface. The inkjet printing system deposits droplets at specific locations and quantities, achieving the minimum necessary coverage for uniform distribution while minimizing waste through exact placement control.
Solution Approach 2:
The patent replaces the mechanical spraying system with an inkjet printing system that uses controlled droplet ejection. This substitution enables precise digital control over droplet placement and quantity, allowing the system to achieve uniform distribution with exact material usage rather than excessive application, thereby reducing waste.
3Reliability
If liquid composition is applied onto matrix material, then bioactive agents are delivered effectively, but matrix swelling occurs which affects device performance
Solution Approach 1:
The patent changes the parameters of liquid composition application by using inkjet printing to deposit smaller, more precisely controlled droplets compared to conventional spraying. This parameter change in application method delivers the necessary bioactive agents while minimizing the total liquid volume contacting the matrix, thereby preventing excessive swelling and maintaining matrix structural stability.
4Productivity
If conventional coating methods are used, then the process is simple, but the distribution of bioactive agents is non-uniform leading to reduced hemostatic efficiency
Solution Approach 1:
The patent replaces conventional coating and spraying mechanical systems with an inkjet printing system. This substitution introduces digital control and precise droplet placement capability, transforming the application process from non-uniform mechanical deposition to controlled, programmable droplet ejection that achieves uniform distribution and maximizes hemostatic efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves a more precise and uniform application of bioactive agents, enhancing hemostatic effects and wound healing by maintaining the bioactive agents' effectiveness while minimizing waste, with a demonstrated sticky effect that aids in dry applications.
Implementation Method 1
a print head, wherein the print head comprises one or more nozzles for depositing droplets of a liquid composition onto a surface
Implementation Method 2
the one or more nozzles for expelling droplets of a liquid composition in a form of a spray or non-spray pattern
Data Source
Figure 1A~1B
Figure 2A
Figure 2B
AI summary
The present invention relates to a matrix material comprising a pharmaceutical composition such as a matrix material with a pharmaceutical composition printed on the surface. In one embodiment the pharmaceutical composition comprises thrombin. The invention further describes a method for making the matrix material with a pharmaceutical composition printed on the surface. In one specific embodiment the invention also relates to the use of said matrix material for promotion of hemostasis and/or wound healing. The invention also relates to a kit-of-parts comprising a matrix with a pharmaceutical composition and a container with a peelable lid.