Inorganic-Coated Solid Nanoparticles for Controlled Drug Release
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Solution Overview
Problem
Existing nanoparticle-based drug delivery systems face challenges such as particle aggregation, Ostwald ripening, and rapid dissolution in solvent, which hinder controlled and targeted drug release, especially for poorly water-soluble drugs.
Innovation Solution
A method involving gas phase atomic layer deposition with intermittent or continuous agitation of nanoparticles to ensure complete inorganic coating, allowing for controlled drug release and targeted delivery by applying multiple layers of inorganic material to a solid core.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If nanoparticles are used for drug delivery, then dissolution rate is enhanced due to increased surface area to mass ratio, but particles may dissolve prematurely before reaching the target
Solution Approach 1:
The patent applies a thin inorganic coating layer (shell) around the nanoparticle core to control dissolution. The coating acts as a barrier that prevents premature dissolution while allowing controlled release of the drug payload, resolving the contradiction between enhanced dissolution rate and controlled release timing.
2Ease of operation
If particles are made small to penetrate cell membranes and barriers, then targeted delivery is improved, but particles require surface functionalizations and protection against premature dissolution
Solution Approach 1:
The inorganic coating serves multiple functions simultaneously: it protects the particle core from premature dissolution, provides a surface for functionalization, and maintains the small size needed for penetration. This multi-functionality reduces the overall complexity of the system by combining several requirements into a single coating structure.
3Reliability
If inorganic coating is applied to nanoparticles, then controlled drug release is achieved, but particle aggregation and Ostwald ripening occur
Solution Approach 1:
The patent carefully controls the thickness and composition parameters of the inorganic coating to prevent aggregation and Ostwald ripening while maintaining controlled release functionality. By optimizing these parameters, the system achieves both reliable drug release and stable particle size distribution.
4Reliability
If multiple layers of inorganic material are applied to ensure complete coating, then protection against premature dissolution is improved, but manufacturing complexity increases
Solution Approach 1:
The patent applies multiple layers of inorganic coating material to ensure complete coverage and adequate protection against premature dissolution. This excessive action (applying more than a single layer) guarantees reliable protection, justifying the increased manufacturing complexity through improved product performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Achieves controlled drug release over a wide time range, high drug load, and targeted delivery across biological barriers, reducing side effects and formulation costs while ensuring biodegradability and easy excretion.
Implementation Method 1
gas phase atomic layer deposition with intermittent or continuous agitation of nanoparticles to ensure complete inorganic coating
Implementation Method 2
intermittent or continuous agitation of nanoparticles to ensure complete inorganic coating
Data Source
AI summary
A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.