Dermatological Sunscreen Base Formulation with Inorganic UV Filters
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing dermatological sun protection preparations face issues with instability, phase separation, and inefficiency in manufacturing processes, particularly when using lamellar layer systems with chemical and physical filters, leading to undesirable effects and reduced application comfort.
Innovation Solution
A process for producing a base formulation comprising an oil phase with UV-absorbing substances and amphiphilic substances forming lamellar structures, involving controlled heating and homogenization, along with the use of coated TiO2 and specific amphiphilic substances like hydrogenated phosphatidylcholine, to create stable and scalable sun protection preparations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If chemical filters are used to achieve long-lasting UV protection, then the duration of protection is improved, but harmful effects such as allergic reactions and cell damage increase
Solution Approach 1:
The patent extracts and removes chemical filter substances from the sunscreen formulation, retaining only physical filters (metal oxides). This eliminates the harmful effects of chemical filters while maintaining UV protection through purely physical mechanisms of scattering, reflection, and absorption by inert mineral particles.
Solution Approach 2:
The patent employs composite material systems combining multiple physical filter particles (titanium dioxide, zinc oxide, aluminium oxide) with specific auxiliary substances to create a stable formulation that achieves long-lasting protection through physical mechanisms alone, without the harmful effects of chemical filters.
2Object-generated harmful factors
If physical filters are used to provide chemically inert UV protection, then harmful effects are reduced, but the protective layer is easily rinsed off with water or sweat
Solution Approach 1:
The patent introduces auxiliary substances including film-forming polymers, silicones, and emollients as intermediary materials that create a water-resistant film on the skin. This film acts as a mediator that anchors the physical filter particles, preventing them from being easily rinsed off by water or sweat while maintaining the chemically inert properties of physical filters.
Solution Approach 2:
The formulation creates a composite system where physical filter particles are embedded in a matrix of water-resistant auxiliary substances. This composite structure provides both the chemical inertness of physical filters and the waterproof stability needed for long-lasting protection during water activities.
3Object-generated harmful factors
If lamellar layer systems with hydrogenated liposomes are used to improve sun protection stability, then skin compatibility is improved, but the manufacturing process becomes very complex and not easily scalable
Solution Approach 1:
The patent extracts and removes hydrogenated liposomes and complex lamellar layer systems from the formulation. Instead, it uses simpler physical filter particles combined with conventional auxiliary substances, thereby eliminating the manufacturing complexity while maintaining skin compatibility through the use of inert physical filters.
Solution Approach 2:
The patent replaces complex, expensive lamellar structures with simpler, more economically manufacturable physical filter formulations. While the protection duration is extended through film-forming auxiliaries rather than complex structures, the manufacturing process becomes significantly simpler and more scalable.
4Object-generated harmful factors
If known manufacturing processes for liposomal sun protection preparations are used, then skin compatibility is improved, but productivity is reduced due to inefficiency and lack of scalability
Solution Approach 1:
The patent removes liposomal and lamellar structures from the formulation, replacing them with simple physical filter-based formulations. This extraction of complex structures enables conventional, efficient manufacturing processes while maintaining skin compatibility through the use of inert physical filters and biocompatible auxiliary substances.
Solution Approach 2:
The patent changes the formulation parameters from complex liposomal systems to simple physical filter formulations with optimized particle sizes and concentrations. This parameter change enables scalable manufacturing using conventional equipment and processes while achieving the desired skin compatibility and protection performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process results in stable, long-lasting, and efficient sun protection preparations with reduced undesirable effects, offering improved skin compatibility and application comfort by minimizing phase separation and enhancing active substance transport.
Implementation Method 1
the filtering effect is purely physical in nature through scattering, reflection and partial absorption with accompanying energy conversion of the UV light
Implementation Method 2
the filtering effect is purely physical in nature through scattering, reflection and partial absorption with accompanying energy conversion of the UV light
Implementation Method 3
the filtering effect is purely physical in nature through scattering, reflection and partial absorption with accompanying energy conversion of the UV light
Implementation Method 4
heats and homogenizes this oil phase in a first step to at least 80° C., preferably at least 90° C., preferably up to a maximum of 96° C.; and in a second step adds at least one UV-absorbing inorganic substance at at least 70° C., preferably at least 75° C., preferably up to a maximum of 82° C.
Implementation Method 5
combines both phases, optionally with the addition of at least one further UV-absorbing substance, and homogenizes the combined product
Implementation Method 6
a water phase comprising the substantial content of amphiphilic substance and heating and homogenizing said water phase to at least 70° C., preferably at least 80° C., preferably up to a maximum of 86° C.
Data Source
AI summary
A process for preparing a base formulation for a dermatological sunscreen composition comprising base formulations comprising oil and water phases and containing a plurality of UV-absorbing substances and at least one amphiphilic substance which forms lamellar structures.