Synergistic Bioactive Composition for ATP Production
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Solution Overview
Problem
Current therapies for enhancing ATP production are inefficient and insufficient in maintaining intracellular ATP levels, particularly for treating ATP deficiency-related disorders, as they either require high energy consumption or have limited solubility and bioavailability.
Innovation Solution
A synergistic bioactive composition combining inosine as a purine nucleoside with hydrophilic pyridinecarboxamide compounds like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), which enhance ATP production through energy-saving pathways by improving solubility and augmenting NAD+ levels, thereby maintaining intracellular ATP levels effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional ATP production therapies are used, then ATP levels may be increased, but energy consumption increases and bioavailability is limited
Solution Approach 1:
The composition provides preliminary action by supplying inosine and nicotinamide riboside that are converted to ATP through energy-saving pathways before cellular energy depletion occurs. The inosine is metabolized through the salvage pathway to generate ATP without requiring the full energy investment of de novo synthesis, thus preparing energy reserves in advance with minimal energy expenditure.
Solution Approach 2:
The invention changes the metabolic parameters by utilizing the purine salvage pathway instead of de novo synthesis. This parameter change allows ATP regeneration from inosine with significantly reduced energy consumption, as the salvage pathway bypasses the energetically expensive steps of building purine rings from scratch, directly converting inosine to inosine monophosphate and then to ATP.
2Quantity of substance
If conventional ATP therapies are used, then some ATP enhancement is achieved, but solubility and bioavailability remain insufficient
Solution Approach 1:
The invention uses a composite material approach by combining inosine with nicotinamide riboside in a synergistic formulation. This composite composition enhances bioavailability through multiple mechanisms: inosine serves as a stable purine nucleoside precursor while nicotinamide riboside provides NAD+ for enhanced cellular uptake and metabolism. The combination creates a synergistic effect that improves solubility and bioavailability beyond what either component could achieve alone.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively increases ATP production with less energy consumption, improving cellular energy reserves and treating various metabolic dysfunctions by restoring ATP levels through both purine salvage and oxidative phosphorylation pathways.
Implementation Method 1
The composition is useful for enhancing hepatic ATP turnover and treating disorders with ATP deficiency through purine salvage pathway
Implementation Method 2
ATP can be produced either aerobically through oxidative phosphorylation, with oxygen as the terminal electron acceptor
Data Source
AI summary
The present invention relates to synergistic bioactive compositions for enhancing cellular energy in aerobic or anaerobic conditions. Particularly, the invention relates to a synergistic bioactive composition comprising specific combination of purine nucleoside and hydrophilic pyridinecarboxamide compound(s) which are present in the ratio of 1:0.1 to 1:1 along with pharmaceutically acceptable carriers/excipients, wherein ‘purine nucleoside’ is inosine adduct and the hydrophilic pyridinecarboxamide compound is selected from nicotinamide riboside or nicotinamide mononucleotide either alone or in combination thereof. Further, the present cellular energy enhancing bioactive compositions are useful for treating ATP deficiency conditions. Moreover, the composition is useful for treating hepatic dysfunctions.