Insecticidal Combinations Synergizing Diamides and Mitochondrial Inhibitors

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Solution Overview

Problem

The increasing resistance of insect pests to modern insecticides and the need for broader disease control spectrum in agriculture necessitate the development of combinations that enhance efficacy and reduce pest pressure while maintaining lower dosages.

Innovation Solution

A combination of diamide or pyrethroid insecticides with mitochondrial complex III electron transport inhibitors, such as bifenazate, to create a synergistic effect that improves insecticidal activity and crop yield by enhancing the control of pests like insects, acarids, and nematodes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If modern insecticides are used to control pest damage, then yield loss is minimized, but insect pest resistance to insecticides increases

Engineering Contradiction:

Improvepest control effectivenessVSAvoidinsect pest resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines multiple insecticides from different chemical classes (anthranilic diamide, pyrethroid, and mitochondrial complex III electron transport inhibitor) into a single formulation. This merging of different modes of action creates a synergistic effect that enhances pest control effectiveness while overcoming resistance development, as each active ingredient attacks the pest through a different physiological pathway

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite insecticidal formulation containing three distinct active ingredients with different chemical structures and modes of action. This composite approach allows the formulation to address multiple resistance mechanisms simultaneously and provides broader spectrum control against diverse pest populations

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If insecticide combinations are used to counteract resistance, then resistance is reduced, but the complexity of the formulation increases

Engineering Contradiction:

Improveinsect pest resistanceVSAvoidformulation complexity

Core Design Contradiction:

Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent merges three different insecticides into a single integrated formulation that can be applied together, simplifying the application process while maintaining the benefits of multiple modes of action. The formulation combines anthranilic diamide, pyrethroid, and mitochondrial complex III electron transport inhibitor in predetermined ratios, eliminating the need for separate applications

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If higher dosages of insecticides are used to overcome resistance, then pest control effectiveness is improved, but crop tolerance decreases and yield is reduced

Engineering Contradiction:

Improvepest control effectivenessVSAvoidcrop yield

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent changes the dosing parameters by using lower individual dosages of each active ingredient while achieving superior pest control through synergistic interaction. The specific dosage ranges disclosed (anthranilic diamide: 0.1-100 g ai/ha, pyrethroid: 0.1-100 g ai/ha, mitochondrial complex III electron transport inhibitor: 0.1-100 g ai/ha) represent optimized parameters that maximize effectiveness while minimizing phytotoxicity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention converts the potential harm of multiple insecticides (which could increase phytotoxicity) into a benefit through synergistic interaction. The combination produces an enhanced effect where the sum of individual activities is exceeded, allowing lower total dosages to achieve the same or better control, thereby protecting crop tolerance and yield

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination significantly enhances the insecticidal and yield-enhancing activities beyond the sum of individual compounds, demonstrating improved disease control and increased crop yield with reduced pest pressure.

Implementation Method 1

at least one mitochondrial complex III electron transport inhibitor

Methodology Applied

Scientific EffectMitochondrial complex III electron transport inhibition:

Implementation Method 2

targeting and disrupting the Ca2+ balance and ryanodine receptor

Methodology Applied

Scientific EffectCalcium balance disruption:

Implementation Method 3

targeting and disrupting the Ca2+ balance and ryanodine receptor

Methodology Applied

Scientific EffectRyanodine receptor disruption:

Data Source

PatentUS12256735B2Insecticidal combinations

Publication Date: 2025.03.25 UPL LTD

AI summary

An Insecticidal combination comprising at least one diamide insecticide; at least one pyrethroid selected and at least one mitochondrial complex III electron transport inhibitor.