Insulin Infusion Controller Closed-Loop Initiation Calibration
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Solution Overview
Problem
Current insulin infusion systems are limited by the speed of insulin delivery and lack efficient control mechanisms to mimic the natural insulin response of a healthy pancreas, leading to suboptimal glucose regulation and potential complications such as excessive weight gain and atherosclerosis.
Innovation Solution
A processor-implemented method and electronic device that estimate the current insulin on board (IOB) value, calculate an IOB rate, and determine an adjusted insulin infusion rate to select a final infusion rate, allowing for closed-loop operation and dynamic adjustment based on real-time glucose monitoring and historical data to emulate the natural insulin secretion pattern of a healthy pancreas.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If traditional external infusion pumps are used to deliver insulin, then continuous insulin delivery is provided, but the system lacks efficient control mechanisms to mimic natural insulin response
Solution Approach 1:
The patent implements a closed-loop control system that continuously monitors glucose levels and adjusts insulin delivery accordingly. The controller receives glucose level signals from sensors, processes this feedback information, and automatically modifies the insulin infusion rate to mimic natural pancreatic response, resolving the contradiction between adaptability and complexity by using intelligent feedback mechanisms.
Solution Approach 2:
The system enables self-regulating insulin delivery through automated control algorithms that simulate the body's natural insulin secretion patterns. The controller automatically adjusts basal and bolus insulin rates based on real-time glucose monitoring, eliminating the need for manual intervention while achieving physiological-like insulin response.
2Speed
If fast acting insulin is used in infusion pumps, then greater control of diabetic condition is achieved, but the speed of insulin delivery remains limited by the pump mechanism
Solution Approach 1:
The patent employs dynamic insulin delivery rates that can be rapidly adjusted in response to glucose level changes. The controller modifies infusion rates in real-time, enabling the system to deliver insulin at variable speeds that better match physiological requirements, overcoming the mechanical limitations of traditional pumps through intelligent rate modulation.
Solution Approach 2:
The system uses periodic glucose monitoring and相应 insulin delivery adjustments to achieve effective control. By sampling glucose levels at regular intervals and delivering insulin in controlled bursts or continuous variable rates, the system mimics the natural periodic insulin secretion patterns while working within pump delivery constraints.
3Reliability
If closed-loop operating mode is implemented, then glucose regulation is improved, but system reliability may be affected by sensor calibration drift
Solution Approach 1:
The patent implements sensor calibration procedures that are performed in advance and at scheduled intervals to maintain measurement accuracy. The system includes calibration factors and offset values that are pre-determined and stored, allowing the controller to compensate for sensor drift before it significantly impacts glucose regulation reliability.
Solution Approach 2:
The system dynamically adjusts sensor calibration parameters based on observed performance and environmental conditions. The controller modifies calibration factors, scaling coefficients, and offset values in response to detected drift patterns, maintaining measurement precision throughout the sensor's operational life and ensuring continued reliability of closed-loop control.
Data Source
AI summary
An electronic controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop initiation module. The initiation module is operated to obtain a most recent calibration factor for a continuous glucose sensor, the most recent calibration factor representing a first conversion value applicable to convert a first sensor value to a first blood glucose value. The initiation module also obtains a prior calibration factor for the sensor, and calibration timestamp data for the most recent calibration factor and the prior calibration factor. The initiation module regulates entry into a closed-loop operating mode of the insulin infusion device, based on the most recent calibration factor, the prior calibration factor, and the calibration timestamp data.