Integrated Bone Regeneration Biomaterial with Layered Structure
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Solution Overview
Problem
Current bone regeneration techniques face challenges in achieving perfect contact between bone graft materials and barrier membranes, leading to reduced success rates due to separate product limitations, such as weak mechanical strength and incomplete close contact, and the use of chemical crosslinking agents can cause toxicity and separation issues.
Innovation Solution
An integrated biomaterial with a lower structure of collagen and bone mineral components and an upper layer of collagen, where the collagen ratio ranges from 0.13-1.3:1, is developed, allowing for organic binding without chemical crosslinking agents, ensuring stable maintenance and preventing connective tissue infiltration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If separate products of bone graft material and barrier membrane are used, then each product can be optimized for its specific function, but perfect close contact between the two products cannot be achieved, reducing bone regeneration success rate
Solution Approach 1:
The patent combines bone graft material and barrier membrane into a single integrated product with a layered structure. The lower layer contains bone graft material for osteoconductivity, while the upper layer contains barrier membrane material to prevent connective tissue infiltration. This merging ensures perfect close contact between the two functional components, eliminating gaps that would occur with separate products, and simultaneously achieves both osteoconductivity and barrier functions in one integrated structure.
2Reliability
If collagen barrier membrane is used, then biocompatibility is improved, but mechanical strength becomes weak and incomplete close contact with bone graft material occurs
Solution Approach 1:
The patent creates a composite material structure where collagen barrier membrane layer is combined with bone graft material layer. The collagen layer provides biocompatibility and prevents connective tissue infiltration, while the bone graft material layer provides mechanical strength and osteoconductivity. This composite approach allows each material to contribute its advantageous properties while compensating for the weaknesses of the other, achieving both high biocompatibility and sufficient mechanical strength.
3Stability of the object's composition
If chemical crosslinking agents are used to bind structures, then structural stability is improved, but toxicity and separation issues occur
Solution Approach 1:
The patent replaces chemical crosslinking agents with a mechanical/physical bonding approach. The barrier membrane layer is physically attached to the bone graft material layer through a bonding process that does not require chemical crosslinking agents. This substitution eliminates the toxicity concerns associated with chemical crosslinking agents while still achieving sufficient structural stability to maintain close contact between layers and prevent separation during implantation and regeneration processes.
Data Source
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AI summary
The present invention relates to an integral biomaterial for regeneration of a bone tissue and a fabrication method therefor and, more particularly, to an integral biomaterial for regeneration of a bone tissue, comprising an infrastructure composed of an extracellular matrix protein and a bone mineral, and a supra layer composed of an extracellular matrix protein, and a method for fabricating the same. The integral biomaterial for regeneration of a bone tissue according to the present invention has an advantage in that the infrastructure composed of an extracellular matrix protein and a bone mineral component reproduces a natural bone tissue environment to facilitate the regeneration of new bones and particularly, the supra layer composed of an extracellular matrix protein is deposited at a suitable ratio to maximize a bone tissue regeneration potential as well as blocking the invasion of an epithelial tissue or a connective tissue.