Integrated Liquid Sample Measurement Arrangement for Small Volumes

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Solution Overview

Problem

Conventional measurement systems for liquid samples are complex and require large amounts of sample solution, making them inefficient for accurate measurements, especially when dealing with small sample volumes, and are prone to contamination and misclassification of electrolyte concentrations.

Innovation Solution

A highly integrated measurement arrangement comprising a first portion with measurement areas and a second portion with a sample input cup, where the reception space is formed by the integration of both parts, allowing for potentiometric, amperometric, and optical measurements with minimal sample volume, reducing contamination risks and enabling direct ion-selective electrode methods.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If conventional measurement systems are used, then measurement capability is provided, but device complexity increases and sample volume requirement increases

Engineering Contradiction:
Improvemeasurement system complexityVSAvoidsample volume
Core Design Contradiction:
Device complexityVSQuantity of substance

Solution Approach 1:

The patent merges the sample input cup and reception space wall section into a single integrally formed component, eliminating the need for separate parts and complex assembly. This integration reduces device complexity while maintaining the functionality to handle small sample volumes efficiently, directly resolving the contradiction between system complexity and sample volume requirements

Inventive Principle:
Principle #5Merging (Combining)

2Reliability

If conventional measurement systems are used, then measurement function is provided, but contamination risk increases

Engineering Contradiction:
Improvemeasurement accuracyVSAvoidcontamination risk
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

By integrating the sample input cup and reception space wall section into one piece, the patent eliminates interfaces and joints where contamination could occur. This integral structure reduces contamination risk and improves measurement reliability, directly addressing the contradiction between measurement accuracy and contamination risk

Inventive Principle:
Principle #5Merging (Combining)

3Ease of manufacture

If conventional measurement systems are used, then measurement capability is provided, but manufacturing complexity increases

Engineering Contradiction:
Improvemanufacturing simplicityVSAvoidsystem structure
Core Design Contradiction:
Ease of manufactureVSDevice complexity

Solution Approach 1:

The patent combines multiple components (sample input cup and reception space wall section) into a single integrally formed part, which simplifies the manufacturing process by reducing the number of parts to produce, assemble, and quality-check. This directly resolves the contradiction between manufacturing simplicity and system structure complexity

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution enables accurate and reliable measurement of electrolytes and other constituents in small sample volumes with reduced contamination and misclassification risks, supporting direct ion-selective electrode methods and minimizing sample usage, while simplifying manufacturing and operation.

Implementation Method 1

The arrangement may in particular be adapted to measure the concentration of at least one ion, such as K+, Ca++, Na+, Cl−, and/or pH

Methodology Applied
Scientific EffectPotentiometric measurement:

Implementation Method 2

The measurement system may be adapted to perform potentiometric and/or amperometric measurement and/or conductometric measurements

Methodology Applied
Scientific EffectAmperometric measurement:

Implementation Method 3

The measurement system may be adapted to perform potentiometric and/or amperometric measurement and/or conductometric measurements

Methodology Applied
Scientific EffectConductometric measurement:

Data Source

PatentUS20220280937A1Arrangement for analyzing a liquid sample
Publication Date: 2022.09.08 EXIAS MEDICAL GMBH
  • US20220280937A1 patent drawing
  • US20220280937A1 patent drawing
  • US20220280937A1 patent drawing

AI summary

It is provided an arrangement and a method for measuring at least one constituent of a liquid sample, in particular comprising serum, plasma and/or urine, the arrangement comprising: a first portion adapted to partly delimit a reception space for the sample at a first side and comprising at least one measurement area; a second portion comprising: a reception space wall section, the second portion being coupled to the first portion such that the reception space wall section partly delimits the reception space at a second side; and a sample input cup delimiting a sample input region into which the sample is fillable, wherein the sample input region is in fluid communication with the reception space, wherein the reception space wall section and at least a portion of the sample input cup are integrally formed.