Integrated Membrane for Biomolecule Preservation

The patent changes the storage parameter from temperature-based (requiring freezers) to chemical composition-based (using stabilizing buffers and adsorbent materials). This allows biomolecules to be preserved at ambient temperatures while maintaining integrity, eliminating the need for complex temperature-controlled storage equipment.

The patent extracts and removes enzymes that cause degradation (such as RNases) from the sample matrix using specific adsorbent materials. By taking out the harmful components rather than relying on cold storage to prevent their activity, the system achieves preservation without temperature control.

The patent introduces an intermediary adsorbent material that selectively binds and removes harmful enzymes from the sample. This intermediary layer protects the biomolecules from degradation without requiring direct contact with harsh preservative chemicals, thus maintaining integrity while minimizing contamination risk.

The patent converts the harmful effect of enzymes into a beneficial separation process. By using adsorbent materials that specifically bind these enzymes, the system transforms the contamination problem into a purification opportunity, where the same materials that could cause contamination are used to remove the contaminants.

The patent segments the separation process into multiple sequential layers within the membrane, each designed to capture specific biomolecule classes. This segmentation allows rapid flow through the membrane while ensuring complete separation, as each layer targets specific molecules without requiring slow, exhaustive processing.

The patent incorporates preliminary action by pre-configuring the membrane with multiple functional layers that are ready to capture different biomolecules as the sample passes through. This preliminary preparation of the separation medium enables rapid processing while maintaining completeness, eliminating the need for sequential manual separation steps.